Dược Động Học :
▧ Absorption :
Upon reaching the body water phase, the decanoate ester is slowly released from the oil depot, which is resultantly hydrolyzed to the active substance, zuclopenthixol. The decanoate ester provides a means of slow release since zuclopenthixol itself is a short-acting drug.
▧ Volume of Distribution :
20 L/kg
▧ Protein binding :
~98%
▧ Metabolism :
Primarily by sulfoxidation, glucuronic acid conjugation, and side chain N-dealkylation. These metabolites are pharmacologically inert.
▧ Route of Elimination :
Primarily in the feces, with about 10% in the urine.
▧ Half Life :
19 days.
▧ Clearance :
0.9 L/min.