Tìm theo
Ethotoin
Các tên gọi khác (10 ) :
  • (+-)-3-Ethyl-5-phenylhydantoin
  • 1-Ethyl-2,5-dioxo-4-phenylimidazolidine
  • 3-Ethyl-5-phenyl-2,4-imidazolidinedione
  • 3-Ethyl-5-phenyl-imidazolidine-2,4-dione
  • 3-Ethyl-5-phenylhydantoin
  • 3-Ethyl-5-phenylimidazolidin-2,4-dione
  • Ethotoin
  • Ethotoïne
  • Ethotoinum
  • Etotoina
Thuốc chống co giật, chống động kinh
Thuốc Gốc
Small Molecule
CAS: 86-35-1
ATC: N03AB01
ĐG : Abbott Laboratories Ltd. , http://www.abbott.com
CTHH: C11H12N2O2
PTK: 204.2252
Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin is no longer commonly used.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H12N2O2
Phân tử khối
204.2252
Monoisotopic mass
204.089877638
InChI
InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15)
InChI Key
InChIKey=SZQIFWWUIBRPBZ-UHFFFAOYSA-N
IUPAC Name
3-ethyl-5-phenylimidazolidine-2,4-dione
Traditional IUPAC Name
ethotoin
SMILES
CCN1C(=O)NC(C1=O)C1=CC=CC=C1
Độ tan chảy
94 °C
Độ hòa tan
5280 mg/L
logP
1.05
logS
-1.9
pKa (strongest acidic)
11.29
pKa (Strongest Basic)
-8.4
PSA
49.41 Å2
Refractivity
55.05 m3·mol-1
Polarizability
20.68 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges.
Cơ Chế Tác Dụng : Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin is no longer commonly used. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin inhibits nerve impulses in the motor cortex by lowering sodium ion influx, limiting tetanic stimulation.
Dược Động Học :
▧ Absorption :
Fairly rapidly absorbed, however, the extent of oral absorption is not known.
▧ Metabolism :
Hepatic. The drug exhibits saturable metabolism with respect to the formation of N-deethyl and p-hydroxyl-ethotoin, the major metabolites.
▧ Half Life :
3 to 9 hours
Độc Tính : Symptoms of overdose include drowsiness, loss of or impaired muscle coordination, nausea, visual disturbance, and, at very high doses, coma.
Chỉ Định : For the control of tonic-clonic (grand mal) and complex partial (psychomotor) seizures.
Tương Tác Thuốc :
  • Alprazolam Ethotoin may increase the metabolism of alprazolam via CYP3A4.
  • Aminophylline Decreased effect of both products
  • Amiodarone Increases the effect of hydantoin
  • Aprepitant The CYP3A4 inducer, ethotoin, may decrease the effect of aprepitant.
  • Betamethasone The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, betamethasone.
  • Capecitabine Capecitabine increases the effect of hydantoin
  • Chloramphenicol Increases phenytoin, modifies chloramphenicol
  • Chlordiazepoxide Ethotoin may increase the metabolism of chlordiazepoxide via CYP3A4.
  • Chlorphenamine The antihistamine increases the effect of hydantoin
  • Cimetidine Increases the effect of hydantoin
  • Ciprofloxacin Decreases the hydantoin effect
  • Clomifene The enzyme inducer, ethotoin, decreases the effect of the hormone agent, clomifene.
  • Clorazepate Ethotoin may increase the metabolism of clorazepate via CYP3A4.
  • Clozapine Hydantoin decreases the effect of clozapine
  • Conjugated Estrogens The enzyme inducer, ethotoin, decreases the effect of the hormone agent, conjugated estrogens.
  • Cyclosporine The hydantoin decreases the effect of cyclosporine
  • Dexamethasone The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, dexamethasone.
  • Diazepam Ethotoin may increase the metabolism of diazepam via CYP3A4.
  • Diethylstilbestrol The enzyme inducer, ethotoin, decreases the effect of the hormone agent, diethylstilbestrol.
  • Disopyramide The hydantoin decreases the effect of disopyramide
  • Disulfiram Increases the effect of phenytoin
  • Doxycycline The anticonvulsant, ethotoin, decreases the effect of doxycycline.
  • Estradiol The enzyme inducer, ethotoin, decreases the effect of the hormone agent, estradiol.
  • Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
  • Felbamate Increased phenytoin levels and decreased felbamate levels
  • Felodipine The hydantoin decreases the effect of felodipine
  • Fluconazole Increases the effect of hydantoin
  • Fludrocortisone The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, fludrocortisone.
  • Fluorouracil Fluorouracil increases the effect of hydantoin
  • Fluoxetine Fluoxetine increases the effect of phenytoin
  • Flurazepam Ethotoin may increase the metabolism of flurazepam via CYP3A4.
  • Fluvoxamine Increases the effect of hydantoin
  • Folic Acid Folic acid decreases the levels of hydantoin
  • Furosemide The hydantoin decreases the effect of furosemide
  • Gabapentin Increases the effect of hydantoin
  • Gefitinib The CYP3A4 inducer, ethotoin, may decrease the serum concentration and therapeutic effects of gefitinib.
  • Hydrocortisone The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, hydrocortisone.
  • Imatinib The hydantoin decreases the levels of imatinib
  • Isoniazid Isoniazid increases the effect of phenytoin in 20% of patients
  • Itraconazole Phenytoin decreases the effect of itraconazole
  • Lamotrigine Phenytoin may reduce levels of lamotrigine
  • Levonorgestrel Phenytoin decreases the contraceptive effect
  • Mebendazole The hydantoin decreases the efficiency of mebendazole
  • Medroxyprogesterone Acetate The enzyme inducer, ethotoin, decreases the effect of the hormone agent, medroxyprogesterone.
  • Megestrol acetate The enzyme inducer, ethotoin, decreases the effect of the hormone agent, megestrol.
  • Methadone The hydantoin decreases the effect of methadone
  • Methotrexate The antineoplasic agent decreases the effect of hydantoin
  • Methoxsalen The hydantoin decreases the effect of psoralene
  • Mexiletine The hydantoin decreases the effect of mexiletine
  • Midazolam Ethotoin may increase the metabolism of midazolam via CYP3A4.
  • Mirtazapine The hydantoins may reduce mirtazapine plasma concentrations and pharmacological effects
  • Norethindrone This product may cause a slight decrease of contraceptive effect
  • Omeprazole Omeprazole increases the effect of hydantoin
  • Oxcarbazepine Oxcarbazepine increases the effect of hydantoin
  • Oxtriphylline Decreased effect of both products
  • Oxyphenbutazone The NSAID, oxyphenbutazone, may increase the hydantoin effect of ethotoin.
  • Phenylbutazone The NSAID, phenylbutazone, may increase the hydantoin effect of ethotoin.
  • Prednisolone The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, prednisolone.
  • Prednisone The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, prednisone.
  • Quetiapine Phenytoin decreases the effect of quetiapine
  • Rifampicin Rifampin decreases the effect of the hydantoin
  • Theophylline Decreased effect of both products
  • Ticlopidine Ticlopidine increases the effect of hydantoin
  • Triamcinolone The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, triamcinolone.
  • Triazolam Ethotoin may increase the metabolism of triazolam via CYP3A4.
  • Triprolidine The CNS depressants, Triprolidine and Ethotoin, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Peganone 250 mg tablet
    Giá bán buôn : USD >1.33
    Đơn vị tính : tablet
Nhà Sản Xuất
  • Sản phẩm biệt dược : Accenon
  • Công ty : Lundbeck
    Sản phẩm biệt dược : Peganone
  • Công ty :
    Sản phẩm biệt dược : Pegoanone
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00754
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3292
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504521
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07839
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00708
ChemSpider
http://www.chemspider.com/Chemical-Structure.3176.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/67386-601-01
PharmGKB
http://www.pharmgkb.org/drug/PA164768735
Wikipedia
http://en.wikipedia.org/wiki/Ethotoin
RxList
http://www.rxlist.com/cgi/generic3/peganone.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/peg1665.shtml
Drugs.com
http://www.drugs.com/cdi/ethotoin.html
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