Tìm theo
Phentermine
Các tên gọi khác (3) :
  • alpha,alpha-Dimethylphenethylamine
  • Fentermina
  • Phenterminum
adrenergic agents, central nervous system stimulants, sympathomimetics, appetite depressants, stimulants
Thuốc Gốc
Small Molecule
CAS: 122-09-8
ATC: A08AA01
ĐG : Apotheca Inc.
CTHH: C10H15N
PTK: 149.2328
A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]. Some common brand names for phentermine are Adipex-P® and Suprenza™. Phentermine is also available in combination medications such as Qsymia®.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H15N
Phân tử khối
149.2328
Monoisotopic mass
149.120449485
InChI
InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3
InChI Key
InChIKey=DHHVAGZRUROJKS-UHFFFAOYSA-N
IUPAC Name
2-methyl-1-phenylpropan-2-amine
Traditional IUPAC Name
phentermine
SMILES
CC(C)(N)CC1=CC=CC=C1
Độ tan chảy
205 °C
Độ hòa tan
18.6 g/L
logP
1.90
logS
-2.3
pKa (Strongest Basic)
10.25
PSA
26.02 Å2
Refractivity
48.34 m3·mol-1
Polarizability
17.87 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Cơ Chế Tác Dụng : A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]. Some common brand names for phentermine are Adipex-P® and Suprenza™. Phentermine is also available in combination medications such as Qsymia®. Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse.Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
Dược Động Học :
▧ Absorption :
Phentermine is rapidly absorbed after oral ingestion.
▧ Protein binding :
Approximately 96.3%
▧ Metabolism :
Hepatic.
▧ Half Life :
16 to 31 hours
Độc Tính : LD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
Chỉ Định : For the treatment and management of obesity.
Tương Tác Thuốc :
  • Acetophenazine Decreased anorexic effect, may increase psychotic symptoms
  • Alimemazine Decreased anorexic effect, may increase psychotic symptoms
  • Chlorpromazine Decreased anorexic effect, may increase psychotic symptoms
  • Ethopropazine Decreased anorexic effect, may increase psychotic symptoms
  • Fluoxetine Risk of serotoninergic syndrome
  • Fluphenazine Decreased anorexic effect, may increase psychotic symptoms
  • Fluvoxamine Risk of serotoninergic syndrome
  • Guanethidine Phentermine may decrease the effect of guanethidine.
  • Isocarboxazid Possible hypertensive crisis
  • Mesoridazine Decreased anorexic effect, may increase psychotic symptoms
  • Methdilazine Decreased anorexic effect, may increase psychotic symptoms
  • Methotrimeprazine Decreased anorexic effect, may increase psychotic symptoms
  • Paroxetine Risk of serotoninergic syndrome
  • Perphenazine Decreased anorexic effect, may increase psychotic symptoms
  • Phenelzine Possible hypertensive crisis
  • Prochlorperazine Decreased anorexic effect, may increase psychotic symptoms.
  • Promazine Decreased anorexic effect, may increase psychotic symptoms
  • Promethazine Decreased anorexic effect, may increase psychotic symptoms.
  • Propericiazine Decreased anorexic effect, may increase psychotic symptoms.
  • Propiomazine Decreased anorexic effect, may increase psychotic symptoms
  • Rasagiline Possible hypertensive crisis
  • Thiethylperazine Decreased anorexic effect, may increase psychotic symptoms
  • Thioridazine Decreased anorexic effect, may increase psychotic symptoms
  • Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
  • Trandolapril Phentermine may reduce the efficacy of Trandolapril.
  • Tranylcypromine The MAO inhibitor, tranylcypromine, may increase the vasopressor effect of the amphetamine, phentermine. Concomitant therapy should be avoided.
  • Trifluoperazine Decreased anorexic effect, may increase psychotic symptoms
  • Triflupromazine Decreased anorexic effect, may increase psychotic symptoms
  • Triprolidine Triprolidine may reduce the sedative effect of the antihistamine, Phentermine.
  • Venlafaxine Risk of serotoninergic syndrome
Liều Lượng & Cách Dùng : Capsule - Oral
Capsule - Oral - 11.25 mg/69 mg (PHENTERMINE HYDROCHLORIDE/ TOPIRAMATE ER)
Capsule - Oral - 15 mg/92 mg (PHENTERMINE HYDROCHLORIDE/ TOPIRAMATE ER)
Capsule - Oral - 3.75 mg/23 mg (PHENTERMINE HYDROCHLORIDE/ TOPIRAMATE ER)
Capsule - Oral - 7.5 mg/46 mg (PHENTERMINE HYDROCHLORIDE/ TOPIRAMATE ER)
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Adipex-P
  • Công ty :
    Sản phẩm biệt dược : Duromine
  • Công ty :
    Sản phẩm biệt dược : Fastin
  • Công ty :
    Sản phẩm biệt dược : Ionamin
  • Công ty :
    Sản phẩm biệt dược : Obenix
  • Công ty :
    Sản phẩm biệt dược : Obestin-30
  • Công ty :
    Sản phẩm biệt dược : Phentercot
  • Công ty :
    Sản phẩm biệt dược : Phentride
  • Công ty :
    Sản phẩm biệt dược : Pro-Fast
  • Công ty : CITIUS PHARMS
    Sản phẩm biệt dược : Suprenza
  • Công ty :
    Sản phẩm biệt dược : Teramine
  • Công ty :
    Sản phẩm biệt dược : Zantryl
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00191
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4771
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508515
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07438
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D05458
ChemSpider
http://www.chemspider.com/Chemical-Structure.4607.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0527-1445-01
PharmGKB
http://www.pharmgkb.org/drug/PA164748099
Wikipedia
http://en.wikipedia.org/wiki/Phentermine
RxList
http://www.rxlist.com/cgi/generic/phenterm.htm
Drugs.com
http://www.drugs.com/phentermine.html
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