Tìm theo
Tiaprofenic acid
Các tên gọi khác (10 ) :
  • 2-(5-Benzoyl-thiophen-2-yl)-propionic acid
  • 2-(5-Benzyl-2-thienyl)propionsaeure
  • 5-Benzoyl-alpha-methyl-2-thiopheneacetic acid
  • 5-Benzoyl-alpha-methylthiophene-2-acetic acid
  • Acide tiaprofenique
  • Acido tiaprofenico
  • Acidum tiaprofenicum
  • alpha-Methyl-5-benzoyl-2-thienylacetic acid
  • Tiaprofensaeure
  • Tiaprofensäure
Thuốc giảm đau, hạ sốt, chống viêm không steroid, điều trị Gút và các bệnh xương khớp
Thuốc Gốc
Small Molecule
CAS: 33005-95-7
ATC: M01AE11
CTHH: C14H12O3S
PTK: 260.308
Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H12O3S
Phân tử khối
260.308
Monoisotopic mass
260.05071494
InChI
InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)
InChI Key
InChIKey=GUHPRPJDBZHYCJ-UHFFFAOYSA-N
IUPAC Name
2-(5-benzoylthiophen-2-yl)propanoic acid
Traditional IUPAC Name
tiaprofenic acid
SMILES
CC(C(O)=O)C1=CC=C(S1)C(=O)C1=CC=CC=C1
Độ tan chảy
96 °C
Độ hòa tan
3.24e-02 g/l
logP
3.66
logS
-3.9
pKa (strongest acidic)
4.03
pKa (Strongest Basic)
-7.8
PSA
54.37 Å2
Refractivity
69.19 m3·mol-1
Polarizability
26.78 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. It is not recommended in children.
Cơ Chế Tác Dụng : Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. Tiaprofenic acid belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a chemical (prostaglandin) which the body produces in response to injury or certain diseases. This prostaglandin would otherwise go on to cause swelling, pain and inflammation.
Dược Động Học :
▧ Absorption :
Bioavailability is 90% following oral administration.
▧ Metabolism :
Hepatic (10%). Sparingly metabolised in the liver to two inactive metabolites.
▧ Half Life :
1.5-2.5 hours
Chỉ Định : Tiaprofenic acid is used to treat pain, especially arthritic pain.
Tương Tác Thuốc :
  • Acenocoumarol Increased risk of bleeding.
  • Acetylsalicylic acid Increased risk of gastrointestinal bleeding.
  • Aminosalicylic Acid Increased risk of gastrointestinal bleeding.
  • Cholestyramine The bile acid sequestrant, Cholestyramine resin, may reduce Tiaprofenic acid absorption and therapeutic effect.
  • Citalopram Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
  • Colesevelam The bile acid sequestrant, Colesevelam, may reduce Tiaprofenic acid absorption and therapeutic effect.
  • Colestipol The bile acid sequestrant, Colestipol, may reduce Tiaprofenic acid absorption and therapeutic effect.
  • Cyclosporine Tiaprofenic acid may increase the nephrotoxicity and/or the serum concentration of cyclosporine. Consider altnerate therapy or monitor for increased cyclosporine concentrations and nephrotoxicity during concomitant therapy.
  • Escitalopram Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
  • Fluoxetine Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
  • Fluvoxamine Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
  • Ginkgo biloba Increased risk of bleeding due to additive antiplatelet properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
  • Ginseng Increased risk of bleeding due to additive antiplatelet properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
  • Ketorolac Concomitant therapy is contraindicated due to the risk of synergistic NSAID toxicity.
  • Lithium Tiaprofenic acid may increase the therapeutic/adverse effects of Lithium by increasing Lithium serum concentrations. Monitor for changes in the therapeutic/adverse effects of Lithium if Tiaprofenic acid is initiated, discontinued or dose changed.
  • Methotrexate Tiaprofenic acid may decrease renal excretion of methotrexate. Consider alternate therapy or monitor for methotrexate toxicity.
  • Paroxetine Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
  • Pemetrexed Tiaprofenic acid may decrease Pemetrexed excretion. Tiaprofenic acid should not be used around the time when Pemetrexed is administered.
  • Salsalate Increased risk of gastrointestinal bleeding.
  • Sertraline Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
  • Telmisartan Concomitant use of Telmisartan and Tiaprofenic acid may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
  • Timolol The NSAID, Tiaprofenic acid, may antagonize the antihypertensive effect of Timolol.
  • Trandolapril The NSAID, Tiaprofenic acid, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Tiaprofenic acid is initiated, discontinued or dose changed.
  • Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Tiaprofenic acid. Monitor for increased bleeding during concomitant thearpy.
  • Warfarin The antiplatelet effects of tiaprofenic acid may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.
Liều Lượng & Cách Dùng : Capsule, extended release - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Surgam
  • Công ty :
    Sản phẩm biệt dược : Surgam SR
  • Công ty :
    Sản phẩm biệt dược : Surgamyl
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01600
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5468
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504590
ChemSpider
http://www.chemspider.com/Chemical-Structure.5269.html
PharmGKB
http://www.pharmgkb.org/drug/PA164764503
Wikipedia
http://en.wikipedia.org/wiki/Tiaprofenic_acid
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