Tìm theo
Quazepam
Các tên gọi khác (2) :
  • Doral
  • Quazepamum
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 36735-22-5
ATC: N05CD10
ĐG : Physicians Total Care Inc. , http://www.physicianstotalcare.com
CTHH: C17H11ClF4N2S
PTK: 386.794
Quazepam is a drug which is a benzodiazepine derivative. It induces impairment of motor function and has hypnotic properties. Quazepam is used to treat insomnia.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H11ClF4N2S
Phân tử khối
386.794
Monoisotopic mass
386.026759579
InChI
InChI=1S/C17H11ClF4N2S/c18-10-5-6-14-12(7-10)16(11-3-1-2-4-13(11)19)23-8-15(25)24(14)9-17(20,21)22/h1-7H,8-9H2
InChI Key
InChIKey=IKMPWMZBZSAONZ-UHFFFAOYSA-N
IUPAC Name
7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-thione
Traditional IUPAC Name
quazepam
SMILES
FC1=CC=CC=C1C1=NCC(=S)N(CC(F)(F)F)C2=C1C=C(Cl)C=C2
Độ tan chảy
137.5-139 °C
Độ hòa tan
2.31e-03 g/l
logP
4.03
logS
-5.2
pKa (strongest acidic)
18.93
pKa (Strongest Basic)
2.59
PSA
15.6 Å2
Refractivity
93.47 m3·mol-1
Polarizability
33.99 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Ghose Filter
true
Dược Lực Học : Quazepam is a benzodiazepine derivative. The main pharmacological action of quazepam is the enhancement of the neurotransmitter, GABA at the GABAA receptor.
Cơ Chế Tác Dụng : Quazepam is a drug which is a benzodiazepine derivative. It induces impairment of motor function and has hypnotic properties. Quazepam is used to treat insomnia. Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Dược Động Học :
▧ Absorption :
Bioavailability is 29-35% following oral administration.
▧ Metabolism :
Hepatic.
▧ Half Life :
39 hours
Chỉ Định : Used to treat insomnia.
Tương Tác Thuốc :
  • Cimetidine Cimetidine may increase the effect of the benzodiazepine, quazepam.
  • Clozapine Increased risk of toxicity
  • Fluconazole Fluconazole may increase the effect of the benzodiazepine, quazepam.
  • Indinavir The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, quazepam.
  • Itraconazole Itraconazole may increase the effect of the benzodiazepine, quazepam.
  • Ketoconazole Ketoconazole may increase the effect of the benzodiazepine, quazepam.
  • Nelfinavir The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, quazepam.
  • Omeprazole Omeprazole may increase the effect of the benzodiazepine, quazepam.
  • Tipranavir Tipranavir may decrease the metabolism and clearance of Quazepam. Consider alternate therapy or monitor for Quazepam toxic effects if Tipranavir is initiated or dose increased.
  • Triprolidine The CNS depressants, Triprolidine and Quazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Doral
  • Công ty :
    Sản phẩm biệt dược : Dormalin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01589
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4999
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505952
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07336
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00457
ChemSpider
http://www.chemspider.com/Chemical-Structure.4825.html
PharmGKB
http://www.pharmgkb.org/drug/PA164744373
Wikipedia
http://en.wikipedia.org/wiki/Quazepam
Drugs.com
http://www.drugs.com/cdi/quazepam.html
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