Pargyline

Các tên gọi khác (6 ) :

Eutonyl
Eutron
Pargyline
SID11111668
SID11111669
SID90340843

Thuốc Gốc

Small Molecule

CAS: 555-57-7

ATC: C02KC01, C02LL01

CTHH: C₁₁H₁₃N

PTK: 159.2276

A monoamine oxidase inhibitor with antihypertensive properties. [PubChem]

Nhận Dạng Quốc Tế & Đặc Tính Hóa Học

Công thức hóa học

C₁₁H₁₃N

Phân tử khối

159.2276

Monoisotopic mass

159.104799421

InChI

InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3

InChI Key

InChIKey=DPWPWRLQFGFJFI-UHFFFAOYSA-N

IUPAC Name

benzyl(methyl)(prop-2-yn-1-yl)amine

Traditional IUPAC Name

benzyl(methyl)prop-2-yn-1-ylamine

SMILES

CN(CC#C)CC1=CC=CC=C1

Độ hòa tan

9.98e-02 g/l

logP

2.14

logS

-3.2

pKa (Strongest Basic)

8.13

PSA

3.24 Å²

Refractivity

52.18 m³·mol^-1

Polarizability

18.78 Å³

Rotatable Bond Count

H Bond Acceptor Count

H Bond Donor Count

Physiological Charge

Number of Rings

Bioavailability

Rule of Five

true

Dược Lực Học : Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as bleu cheese and beer, as this can lead to a hypertensive crisis.

Cơ Chế Tác Dụng : A monoamine oxidase inhibitor with antihypertensive properties. [PubChem] MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Pargyline functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Catecholamines cause general physiological changes that prepare the body for physical activity (fight-or-flight response). Some typical effects are increases in heart rate, blood pressure, blood glucose levels, and a general reaction of the sympathetic nervous system.

Chỉ Định : For the treatment of moderate to severe hypertension.

Tương Tác Thuốc :

Epinephrine Increased arterial pressure
Fenoterol Increased arterial pressure
Guanethidine Pargyline may decrease the effect of guanethidine.
Methotrimeprazine Possible severe adverse reaction with this combination
Milnacipran Increase serotonin levels. Combination therapy is contraindicated.
Orciprenaline Increased arterial pressure
Phenylephrine Increased arterial pressure
Phenylpropanolamine Increased arterial pressure
Pseudoephedrine Increased arterial pressure
Terbutaline Increased arterial pressure

Dữ Kiện Thương Mại

Nhà Sản Xuất

Công ty :

Sản phẩm biệt dược : Eutonyl

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB01626

PubChem Compound

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4688

PubChem Substance

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507368

KEGG Compound

http://www.genome.jp/dbget-bin/www_bget?cpd:C07414

ChemSpider

http://www.chemspider.com/Chemical-Structure.4526.html

BindingDB

http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172756

PharmGKB

http://www.pharmgkb.org/drug/PA450797

Wikipedia

http://en.wikipedia.org/wiki/Pargyline

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