Tìm theo
Dihydroquinidine barbiturate
Thuốc Gốc
Small Molecule
Cơ Chế Tác Dụng : Barbiturates work by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS.
Tương Tác Thuốc :
  • Amiloride Decreases the antiarrhythmic effect of quinidine
  • Aminophylline The barbiturate, dihydroquinidine barbiturate, decreases the effect of aminophylline.
  • Amiodarone Increases the effect of quinidine
  • Amitriptyline Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, amitriptyline.
  • Aripiprazole Quinidine increases the effect and toxicity of aripiprazole
  • Atazanavir Increased risk of cardiotoxicity and arrhythmias
  • Betamethasone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, betamethasone.
  • Cimetidine Increases the effect of quinidine
  • Cisapride Increased risk of cardiotoxicity and arrhythmias
  • Clomipramine Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, clomipramine.
  • Codeine Quinidine decreases the analgesic effect of codeine
  • Cyclosporine The barbiturate, dihydroquinidine barbiturate, increases the effect of cyclosporine.
  • Desipramine Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, desipramine.
  • Dexamethasone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, dexamethasone.
  • Dextromethorphan Quinidine increases the toxicity of dextromethorphan
  • Digoxin Quinine/quinidine increases the effect of digoxin
  • Diltiazem Increases the effect and toxicity of quinidine
  • Doxepin Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, doxepin.
  • Doxycycline The anticonvulsant, dihydroquinidine barbiturate, decreases the effect of doxycycline.
  • Felodipine The barbiturate, dihydroquinidine barbiturate, decreases the effect of felodipine.
  • Fludrocortisone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, fludrocortisone.
  • Folic Acid Folic acid decreases the effect of anticonvulsant, dihydroquinidine barbiturate.
  • Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
  • Gefitinib The CYP3A4 inducer, dihydroquinidine barbiturate, may decrease the serum concentration and therapeutic effects of gefitinib.
  • Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
  • Griseofulvin The barbiturate, dihydroquinidine barbiturate, decreases the effect of griseofulvin.
  • Hydrocortisone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, hydrocortisone.
  • Imipramine Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, imipramine.
  • Levofloxacin Increased risk of cardiotoxicity and arrhythmias
  • Levonorgestrel Phenobarbital decreases the effect of levonorgestrel
  • Magnesium The antiacid decreases the absorption of quinidine
  • Methadone The barbiturate, dihydroquinidine barbiturate, decreases the effect of methadone.
  • Metronidazole The barbiturate, dihydroquinidine barbiturate, decreases the effect of metronidazole.
  • Moxifloxacin Increased risk of cardiotoxicity and arrhythmias
  • Nelfinavir Nelfinavir increases the effect and toxicity of quindine
  • Nifedipine Decreased quinidine effect, increased nifedipine effect
  • Nortriptyline Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, nortriptyline.
  • Ofloxacin Increased risk of cardiotoxicity and arrhythmias
  • Oxtriphylline The barbiturate, dihydroquinidine barbiturate, decreases the effect of oxtriphylline.
  • Prednisolone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, prednisolone.
  • Prednisone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, prednisone.
  • Procainamide Quinidine increases the effect of procainamide
  • Propafenone Quinidine increases the effect of propafenone
  • Quinidine The anticonvulsant, dihydroquinidine. barbiturate, decreases the effect of quinidine.
  • Quinupristin This combination presents an increased risk of toxicity
  • Theophylline The barbiturate, dihydroquinidine barbiturate, decreases the effect of theophylline.
  • Triamcinolone The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, triamcinolone.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01341
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