Tìm theo
Dextroamphetamine
Các tên gọi khác (14 ) :
  • (+)-(S)-amphetamine
  • (+)-alpha-Methylphenethylamine
  • (+)-alpha-Methylphenylethylamine
  • (+)-Amphetamine
  • (AlphaS)-alpha-methylbenzeneethanamine
  • (S)-(+)-Amphetamine
  • (S)-(+)-beta-Phenylisopropylamine
  • (S)-1-Phenyl-2-aminopropane
  • (S)-1-Phenyl-2-propylamine
  • (S)-alpha-Methylbenzeneethanamine
  • (S)-amphetamine
  • d-amphetamine
  • dexamphetamine
  • Dextroamphetamine
central nervous system stimulants, dopamine uptake inhibitors
Thuốc Gốc
Small Molecule
CAS: 51-64-9
ATC: N06BA02
ĐG : Abbott Laboratories Ltd. , http://www.abbott.com
CTHH: C9H13N
PTK: 135.2062
Dextroamphetamine is the dextrorotary stereoisomer of the amphetamine molecule, which can take two different forms. It is a slightly polar, weak base and is lipophilic.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H13N
Phân tử khối
135.2062
Monoisotopic mass
135.104799421
InChI
InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1
InChI Key
InChIKey=KWTSXDURSIMDCE-QMMMGPOBSA-N
IUPAC Name
(2S)-1-phenylpropan-2-amine
Traditional IUPAC Name
amphetamine
SMILES
C[C@H](N)CC1=CC=CC=C1
Độ tan chảy
< 25 °C
Độ sôi
203 °C
Độ hòa tan
1.74e+00 g/l
logP
1.76
logS
-1.9
pKa (Strongest Basic)
10.01
PSA
26.02 Å2
Refractivity
43.71 m3·mol-1
Polarizability
16.08 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
9.9
Dược Lực Học : Amphetamines such as dextroamphetamine are noncatecholamine, sympathomimetic amines with CNS stimulant activity. Peripheral actions include elevations of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action. There is neither specific evidence that clearly establishes the mechanism whereby amphetamines produce mental and behavioral effects in children, nor conclusive evidence regarding how these effects relate to the condition of the central nervous system.
Cơ Chế Tác Dụng : Dextroamphetamine is the dextrorotary stereoisomer of the amphetamine molecule, which can take two different forms. It is a slightly polar, weak base and is lipophilic. The exact mechanism of action is not known. Dextroamphetamine stimulates the release of norepinephrine from central adrenergic receptors. At higher dosages, it causes release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems by reversal of the monoamine transporters. Dextroamphetamine may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetamines are believed to cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Modulation of serotonergic pathways may contribute to the calming affect.
Dược Động Học :
▧ Absorption :
Oral bioavailability is over 75%.
▧ Metabolism :
Hepatic.
▧ Half Life :
10-28 hours (average is approximately 12 hours)
Độc Tính : In rats, the oral LD50 of dextroamphetamine sulfate is 96.8 mg/kg. Manifestations of acute overdosage with amphetamines include restlessness, tremor, hyperreflexia, rhabdomyolysis, rapid respiration, hyperpyrexia, confusion, assaultiveness, hallucinations, panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Fatal poisoning is usually preceded by convulsions and coma.
Chỉ Định : Used to treat attention deficit hyperactivity disorder (ADHD).
Tương Tác Thuốc :
  • Chlorpromazine Decreased anorexic effect, may increases psychotic symptoms
  • Fluoxetine Risk of serotoninergic syndrome
  • Fluphenazine Decreased anorexic effect, may increase psychotic symptoms
  • Fluvoxamine Risk of serotoninergic syndrome
  • Guanethidine Dextroamphetamine may decrease the effect of guanethidine.
  • Isocarboxazid Possible hypertensive crisis
  • Mesoridazine Decreased anorexic effect, may increase psychotic symptoms
  • Methotrimeprazine Decreased anorexic effect, may increase psychotic symptoms
  • Paroxetine Risk of serotoninergic syndrome
  • Perphenazine Decreased anorexic effect, may increase psychotic symptoms
  • Phenelzine Possible hypertensive crisis
  • Prochlorperazine Decreased anorexic effect, may increase pyschotic symptoms
  • Promethazine Decreased anorexic effect, may increase pyschotic symptoms
  • Propericiazine Decreased anorexic effect, may increase pyschotic symptoms
  • Rasagiline Possible hypertensive crisis
  • Thioridazine Decreased anorexic effect, may increase psychotic symptoms
  • Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
  • Trandolapril Dextroamphetamine may reduce the efficacy of Trandolapril.
  • Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the vasopressor effect of the amphetamine, Dextroamphetamine. Concomitant therapy should be avoided.
  • Trifluoperazine Decreased anorexic effect, may increase psychotic symptoms
  • Triprolidine Triprolidine may reduce the sedative effect of the antihistamine, Dextroamphetamine.
Liều Lượng & Cách Dùng : Capsule, extended release - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Medice
    Sản phẩm biệt dược : Attentin
  • Công ty : Sigma
    Sản phẩm biệt dược : Dexamphetamine
  • Công ty : CorePharma
    Sản phẩm biệt dược : Dexedrine
  • Công ty :
    Sản phẩm biệt dược : ProCentra
  • Công ty :
    Sản phẩm biệt dược : Zenzedi
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01576
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5826
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506252
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07884
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D03740
ChemSpider
http://www.chemspider.com/Chemical-Structure.5621.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0007-3512-59
PharmGKB
http://www.pharmgkb.org/drug/PA449269
Wikipedia
http://en.wikipedia.org/wiki/Dextroamphetamine
RxList
http://www.rxlist.com/cgi/generic/dextroamphetamine.htm
Drugs.com
http://www.drugs.com/cdi/dextroamphetamine.html
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