Tìm theo
Dexfenfluramine
Các tên gọi khác (8 ) :
  • (+)-fenfluramine
  • (S)-fenfluramine
  • (S)-N-Ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
  • D-N-Ethyl-alpha-methyl-m-trifluoromethylphenethylamine
  • Dexfenfluramina
  • Dexfenfluramine
  • Dexfenfluraminum
  • Dextrofenfluramine
serotonin uptake inhibitors, anti obesity agents, serotonin receptor agonists
Thuốc Gốc
Small Molecule
CAS: 3239-44-9
CTHH: C12H16F3N
PTK: 231.2573
Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H16F3N
Phân tử khối
231.2573
Monoisotopic mass
231.123484132
InChI
InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1
InChI Key
InChIKey=DBGIVFWFUFKIQN-VIFPVBQESA-N
IUPAC Name
ethyl[(2S)-1-[3-(trifluoromethyl)phenyl]propan-2-yl]amine
Traditional IUPAC Name
(+)-fenfluramine
SMILES
CCN[C@@H](C)CC1=CC=CC(=C1)C(F)(F)F
Độ hòa tan
2.15e-02 g/l
logP
3.5
logS
-4
pKa (Strongest Basic)
10.22
PSA
12.03 Å2
Refractivity
59.2 m3·mol-1
Polarizability
22.69 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Dexfenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes.
Cơ Chế Tác Dụng : Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn. Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.
Dược Động Học :
▧ Absorption :
Well-absorbed from the gastrointestinal tract.
▧ Protein binding :
36%
▧ Half Life :
17-20 hours
Độc Tính : Symptoms of overdose include respiratory failure and cardiac arrest leading to death.
Chỉ Định : For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Adifax
  • Công ty :
    Sản phẩm biệt dược : Redux
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01191
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07805
PharmGKB
http://www.pharmgkb.org/drug/PA164747936
Wikipedia
http://en.wikipedia.org/wiki/Dexfenfluramine
RxList
http://www.rxlist.com/cgi/generic/dexfen.htm
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