Tìm theo
Deserpidine
Các tên gọi khác (10 ) :
  • (3beta,16beta,17alpha,18beta,20alpha)-17-Methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
  • 11-demethoxyreserpine
  • 11-desmethoxyreserpine
  • Canescine
  • Deserpidina
  • Deserpidine
  • Deserpidinum
  • Harmonyl
  • Raunormine
  • Recanescine
Thuốc Gốc
Small Molecule
CAS: 131-01-1
ATC: C02AA05
CTHH: C32H38N2O8
PTK: 578.6527
Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C32H38N2O8
Phân tử khối
578.6527
Monoisotopic mass
578.262816202
InChI
InChI=1S/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,21+,23-,26-,27+,30+/m1/s1
InChI Key
InChIKey=CVBMAZKKCSYWQR-WCGOZPBSSA-N
IUPAC Name
methyl (1R,15S,17R,18R,19S,20S)-18-methoxy-17-[(3,4,5-trimethoxyphenyl)carbonyloxy]-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate
Traditional IUPAC Name
deserpidine
SMILES
[H][C@]12C[C@@H](OC(=O)C3=CC(OC)=C(OC)C(OC)=C3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]1([H])N(CCC3=C1NC1=CC=CC=C31)C2
Độ tan chảy
228-232
Độ hòa tan
1.11e-02 g/l
logP
3.3
logS
-4.7
pKa (strongest acidic)
16.37
pKa (Strongest Basic)
7.57
PSA
108.55 Å2
Refractivity
154.96 m3·mol-1
Polarizability
62.59 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
7
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
6
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Deserpidine, an alkaloid of Rauwolfia canescens, is used as an antihypertensive. Rauwolfia alkaloids work by controlling nerve impulses along certain nerve pathways. As a result, they act on the heart and blood vessels to lower blood pressure.
Cơ Chế Tác Dụng : Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.
Độc Tính : Symptoms of overdose include dizziness or drowsiness (severe), flushing of skin, pinpoint pupils of eyes and slowed pulse.
Chỉ Định : For the treatment of hypertension.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Abbott
    Sản phẩm biệt dược : Harmonyl
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01089
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=8550
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505311
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06541
ChemSpider
http://www.chemspider.com/Chemical-Structure.8232.html
PharmGKB
http://www.pharmgkb.org/drug/PA164742966
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