Dược Động Học :
▧ Absorption :
Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In
▧ Protein binding :
▧ Metabolism :
Subject to extensive first-pass hepatic biotransformation (primarily to diacetolol).
▧ Route of Elimination :
Elimination via renal excretion is approximately 30% to 40% and by non-renal mechanisms 50% to 60%, which includes excretion into the bile and direct passage through the intestinal wall.
▧ Half Life :
The plasma elimination half-life is approximately 3 to 4 hours. The half-life of its metabolite, diacetolol, is 8 to 13 hours.