Investigated for use/treatment in myelodysplastic syndrome.

Investigated for use/treatment in peripheral vascular disease and raynaud's disease.

Investigated for use/treatment in various forms of brain cancer; Malignant Glioma, Glioblastoma Multiforme, GBM, Anaplastic Astrocytoma, Oligo-Astrocytoma, Gliosarcoma

Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine...

Investigated for use/treatment in diabetes mellitus (type 2).

Investigated for use/treatment in leukemia (myeloid).

Investigated for use/treatment in depression and anxiety.

Investigated for use/treatment in emphysema.

Investigated for use/treatment in asthma.

Investigated for use/treatment in urinary incontinence.

Investigated for use/treatment in coronary artery disease, inflammatory disorders (unspecified), and rheumatoid arthritis.

Investigated for use/treatment in autoimmune diseases, cancer/tumors (unspecified), lymphoma (non-hodgkin's), and lymphoma (unspecified).

Investigated for use/treatment in hepatitis (viral, C).

Investigated for use/treatment in saliva and salivary gland dysfunction (sialorrhea).

Investigated for use/treatment in inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.

Investigated for use/treatment in hepatitis (viral, C), infectious and parasitic disease (unspecified), and tuberculosis.

Investigated for use/treatment in solid tumors.

Investigated for use/treatment in cancer/tumors (unspecified) and ovarian cancer.

Investigated for use as a prodrug for Hepsera in treating hepatitis (viral, B).

Investigated for use/treatment in candidiasis and vaginitis.