Tìm theo
131-I-TM-601
Các tên gọi khác (1) :
  • TM-601
Thuốc Gốc
Small Molecule
CTHH: C26H31NO
PTK: 373.5304
131-I-TM-601 is investigated in clinical trials for treating brain cancer. 131-I-TM-601 is a solid. Tx binds to and reduces the activity of a matrix metalloproteinase (MMP) that regulates functioning of the chloride channels on cell membranes. TM-601 is a small 36-amino-acid peptide that selectively binds to glioma cells but not normal brain parenchyma. It is a synthetic version of a neurotoxin isolated from the venom of the Giant Yellow Israeli scorpion Leiurus quinquestriatus. The synthetic version of this peptide has been manufactured and covalently linked to iodine 131 ((131)I-TM-601) as a means of targeting radiation to tumor cells in the treatment of brain cancer. The selective effects of TM-601 are regulated by its action on MMP2 receptors.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C26H31NO
Phân tử khối
373.5304
Monoisotopic mass
373.240564619
InChI
InChI=1S/C26H31NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18,25-26H,4,19-20H2,1-3H3
InChI Key
InChIKey=YUFAHBUWIVNVNJ-UHFFFAOYSA-N
IUPAC Name
{2-[4-(1,2-diphenylbutyl)phenoxy]ethyl}dimethylamine
Traditional IUPAC Name
{2-[4-(1,2-diphenylbutyl)phenoxy]ethyl}dimethylamine
SMILES
CCC(C(C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1
Độ hòa tan
6.91e-05 g/l
logP
6.52
logS
-6.7
pKa (Strongest Basic)
8.78
PSA
12.47 Å2
Refractivity
118.67 m3·mol-1
Polarizability
44.5 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : As a synthetic version of a neurotoxin isolated from the venom of the Giant Yellow Israeli scorpion Leiurus Quinquestriatus, TM-601 is a small 36 amino acid peptide that has been manufactured and covalently linked to iodine 131 ((131)I-TM-601). Its unique binding to gliomal cells makes it a unique means of targeting radiation to tumor cells in the treatment of brain cancer.
Cơ Chế Tác Dụng : 131-I-TM-601 is investigated in clinical trials for treating brain cancer. 131-I-TM-601 is a solid. Tx binds to and reduces the activity of a matrix metalloproteinase (MMP) that regulates functioning of the chloride channels on cell membranes. TM-601 is a small 36-amino-acid peptide that selectively binds to glioma cells but not normal brain parenchyma. It is a synthetic version of a neurotoxin isolated from the venom of the Giant Yellow Israeli scorpion Leiurus quinquestriatus. The synthetic version of this peptide has been manufactured and covalently linked to iodine 131 ((131)I-TM-601) as a means of targeting radiation to tumor cells in the treatment of brain cancer. The selective effects of TM-601 are regulated by its action on MMP2 receptors. TX binds to and reduces the activity of a matrix metalloproteinase (MMP) that is regulates functioning of the chloride channels on cell membranes. CTX reduced the migration ability of glioma cells through tight extracellular spaces in the brain tissue by inhibition of the MMP2, because this prevented the cells from shrinking and releasing from the extracellular matrix.
Độc Tính : Found safe in clinical trials.
Chỉ Định : Investigated for use/treatment in various forms of brain cancer; Malignant Glioma, Glioblastoma Multiforme, GBM, Anaplastic Astrocytoma, Oligo-Astrocytoma, Gliosarcoma
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05462
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4369566
ChemSpider
http://www.chemspider.com/Chemical-Structure.3572093.html
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