Tìm theo
Tubocurarine
Các tên gọi khác (4 ) :
  • (+)-tubocurarine
  • 7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium
  • d-tubocurarine
  • Tubocurarin
neuromuscular nondepolarizing agents, nicotinic antagonists, muscle relaxant skeletal
Thuốc Gốc
Small Molecule
CAS: 6989-98-6
ATC: M03AA02
ĐG : Hospira Inc. , http://www.hospira.com
CTHH: C37H41N2O6
PTK: 609.7312
A neuromuscular blocker and active ingredient in curare; plant based alkaloid of Menispermaceae. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C37H41N2O6
Phân tử khối
609.7312
Monoisotopic mass
609.296462054
InChI
InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1
InChI Key
InChIKey=JFJZZMVDLULRGK-URLMMPGGSA-O
IUPAC Name
(1S,16R)-9,21-dihydroxy-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{18,22}.0^{27,31}.0^{16,34}]hexatriaconta-3,5,8,10,12(34),18(33),19,21,24(32),25,27(31),35-dodecaen-15-ium
Traditional IUPAC Name
(1S,16R)-9,21-dihydroxy-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{18,22}.0^{27,31}.0^{16,34}]hexatriaconta-3,5,8,10,12(34),18(33),19,21,24(32),25,27(31),35-dodecaen-15-ium
SMILES
[H][C@@]12CC3=CC=C(OC4=C5C(CC[N+](C)(C)[C@]5([H])CC5=CC(OC6=C(OC)C=C(CCN1C)C2=C6)=C(O)C=C5)=CC(OC)=C4O)C=C3
Độ hòa tan
3.23e-04 g/l
logP
3.14
logS
-6.3
pKa (strongest acidic)
6.45
pKa (Strongest Basic)
8.12
PSA
80.62 Å2
Refractivity
187.06 m3·mol-1
Polarizability
66.41 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
7
Bioavailability
1
Dược Lực Học : Tubocurarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom.
Cơ Chế Tác Dụng : A neuromuscular blocker and active ingredient in curare; plant based alkaloid of Menispermaceae. [PubChem] Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH.
Dược Động Học :

▧ Half Life :
1-2 hours
Chỉ Định : Used as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure
Tương Tác Thuốc :
  • Amikacin The agent increases the effect of muscle relaxant
  • Aminophylline Theophylline decreases the effect of muscle relaxant
  • Azathioprine The agent decreases the effect of the muscle relaxant
  • Carbamazepine Decreases the effect of muscle relaxant
  • Clindamycin The agent increases the effect of muscle relaxant
  • Fosphenytoin Phenytoin decreases the effect of muscle relaxant
  • Gentamicin The agent increases the effect of muscle relaxant
  • Lincomycin The agent increases the effect of muscle relaxant
  • Mercaptopurine The agent dereases the effect of the muscle relaxant
  • Netilmicin The agent increases the effect of muscle relaxant
  • Oxtriphylline Theophylline decreases the effect of muscle relaxant
  • Phenytoin Phenytoin decreases the effect of the muscle relaxant
  • Piperacillin The agent increases the effect of the muscle relaxant
  • Theophylline Theophylline decreases the effect of the muscle relaxant
  • Tobramycin The agent increases the effect of the muscle relaxant
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Tubarine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01199
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6000
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505279
ChemSpider
http://www.chemspider.com/Chemical-Structure.5778.html
PharmGKB
http://www.pharmgkb.org/drug/PA451811
Wikipedia
http://en.wikipedia.org/wiki/Tubocurarine
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