Tìm theo
Troleandomycin
Các tên gọi khác (3) :
  • TAO
  • Triacetyloleandomycin
  • Troleandomycin
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 2751-09-9
CTHH: C41H67NO15
PTK: 813.9684
A macrolide antibiotic that is similar to erythromycin.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C41H67NO15
Phân tử khối
813.9684
Monoisotopic mass
813.451070479
InChI
InChI=1S/C41H67NO15/c1-19-17-41(18-49-41)38(46)23(5)34(53-27(9)43)21(3)25(7)52-39(47)24(6)35(56-32-16-31(48-14)36(26(8)51-32)54-28(10)44)22(4)33(19)57-40-37(55-29(11)45)30(42(12)13)15-20(2)50-40/h19-26,30-37,40H,15-18H2,1-14H3/t19-,20+,21-,22+,23+,24+,25+,26-,30-,31-,32-,33-,34-,35-,36-,37+,40-,41+/m0/s1
InChI Key
InChIKey=LQCLVBQBTUVCEQ-QTFUVMRISA-N
IUPAC Name
(3R,5R,6S,7S,8R,11R,12S,13R,14S,15S)-14-{[(2S,3R,4S,6R)-3-(acetyloxy)-4-(dimethylamino)-6-methyloxan-2-yl]oxy}-12-{[(2R,4S,5S,6S)-5-(acetyloxy)-4-methoxy-6-methyloxan-2-yl]oxy}-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadecan-6-yl acetate
Traditional IUPAC Name
troleandomycin
SMILES
CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(C)=O)N(C)C)[C@@H](C)C[C@@]3(CO3)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1OC(C)=O
Độ hòa tan
1.92e-02 g/l
logP
4.3
logS
-4.6
pKa (strongest acidic)
16.75
pKa (Strongest Basic)
7.87
PSA
184.19 Å2
Refractivity
201.15 m3·mol-1
Polarizability
86.08 Å3
Rotatable Bond Count
12
H Bond Acceptor Count
12
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Troleandomycin is a macrolide antibiotic that is similar to erythromycin. It is active in vitro against the following gram-positive organisms: Streptococcus pyogenes and Diplococcus pneumoniae.
Cơ Chế Tác Dụng : A macrolide antibiotic that is similar to erythromycin. Troleandomycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the "P" or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the "A" or acceptor site to the "P" or donor site is prevented, and subsequent protein synthesis is inhibited.
Độc Tính : Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.
Chỉ Định : For the treatment of Pneumococcal pneumonia due to susceptible strains and group A beta-hemolytic streptococcal infections of the upper respiratory tract.
Tương Tác Thuốc :
  • Aminophylline The macrolide, troleandomycin, may increase the effect and toxicity of theophylline derivative, aminophylline.
  • Aprepitant This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
  • Astemizole Increased risk of cardiotoxicity and arrhythmias
  • Carbamazepine The macrolide, troleandomycin, may increase the effect of carbamazepine.
  • Cisapride Increased risk of cardiotoxicity and arrhythmias
  • Citalopram Possible serotoninergic syndrome with this combination
  • Colchicine Severe colchicine toxicity can occur
  • Cyclosporine The macrolide, troleandomycin, may increase the effect of cyclosporine.
  • Dihydroergotamine Possible ergotism and severe ischemia with this combination
  • Eletriptan The macrolide, troleandomycin, may increase the effect and toxicity of eletriptan.
  • Eplerenone The macrolide, troleandomycin, may increase the effect and toxicity of eplerenone.
  • Ergotamine Possible ergotism and severe ischemia with this combination
  • Erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib
  • Fluoxetine Possible serotoninergic syndrome with this combination
  • Methysergide Possible ergotism and severe ischemia with this combination
  • Oxtriphylline The macrolide, troleandomycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
  • Pimozide Increased risk of cardiotoxicity and arrhythmias
  • Tacrolimus The macrolide antibiotic, Troleandomycin, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Troleandomycin therapy is initiated, discontinued or altered.
  • Terfenadine Increased risk of cardiotoxicity and arrhythmias
  • Theophylline The macrolide, troleandomycin, may increase the effect and toxicity of theophylline.
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Tao
  • Công ty :
    Sản phẩm biệt dược : Triocetin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01361
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=202225
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508062
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C12753
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01322
ChemSpider
http://www.chemspider.com/Chemical-Structure.16707.html
PharmGKB
http://www.pharmgkb.org/drug/PA127840611
Wikipedia
http://en.wikipedia.org/wiki/Troleandomycin
RxList
http://www.rxlist.com/cgi/generic/troleandomycin.htm
Drugs.com
http://www.drugs.com/mtm/troleandomycin.html
... loading
... loading