Tìm theo
Secobarbital
Các tên gọi khác (10 ) :
  • (+-)-Secobarbital
  • (±)-secobarbital
  • 5-(1-Methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
  • 5-Allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
  • 5-allyl-5-(1-methylbutyl)barbituric acid
  • 5-Allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione
  • Quinalbarbitone
  • Secobarbitalum
  • Secobarbitone
  • Seconal
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 76-73-3
ATC: N05CA06
ĐG : Marathon Pharmaceuticals , http://www.marathonpharma.com
CTHH: C12H18N2O3
PTK: 238.2829
Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal® and Tuinal) is a barbiturate derivative drug. It possesses anaesthetic, anticonvulsant, sedative and hypnotic properties. In the United Kingdom, it was known as Quinalbarbitone.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H18N2O3
Phân tử khối
238.2829
Monoisotopic mass
238.131742452
InChI
InChI=1S/C12H18N2O3/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)
InChI Key
InChIKey=KQPKPCNLIDLUMF-UHFFFAOYSA-N
IUPAC Name
5-(pentan-2-yl)-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
Traditional IUPAC Name
secobarbital
SMILES
CCCC(C)C1(CC=C)C(=O)NC(=O)NC1=O
Độ tan chảy
100 °C
Độ hòa tan
550 mg/L
logP
1.97
logS
-2.3
pKa (strongest acidic)
8.48
PSA
75.27 Å2
Refractivity
62.65 m3·mol-1
Polarizability
24.33 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
7.8
Dược Lực Học : Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
Cơ Chế Tác Dụng : Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal® and Tuinal) is a barbiturate derivative drug. It possesses anaesthetic, anticonvulsant, sedative and hypnotic properties. In the United Kingdom, it was known as Quinalbarbitone. Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Dược Động Học :

▧ Route of Elimination :
Barbiturates are metabolized primarily by the hepatic microsomal enzyme system, and the metabolic products are excreted in the urine and, less commonly, in the feces.
Độc Tính : Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Chỉ Định : For the Short-term treatment of intractable insomnia for patients habituated to barbiturates
Tương Tác Thuốc :
  • Aminophylline The barbiturate, secobarbital, decreases the effect of aminophylline.
  • Bendamustine CYP1A2 metabolism may result in increased levels of active metabolites, decreases levels of bendamustine.
  • Betamethasone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, betamethasone.
  • Clomifene The enzyme inducer, secobarbital, decreases the effect of the hormone agent, clomifene.
  • Conjugated Estrogens The enzyme inducer, secobarbital, decreases the effect of the hormone agent, conjugated estrogens.
  • Cyclosporine The barbiturate, secobarbital, increases the effect of cyclosporine.
  • Dexamethasone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, dexamethasone.
  • Diethylstilbestrol The enzyme inducer, secobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
  • Doxycycline The anticonvulsant , secobarbital, decreases the effect of doxycycline.
  • Estradiol The enzyme inducer, secobarbital, decreases the effect of the hormone agent, estradiol.
  • Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
  • Felodipine The barbiturate, secobarbital, decreases the effect of felodipine.
  • Fludrocortisone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
  • Folic Acid Folic acid decreases the effect of anticonvulsant, secobarbital.
  • Gefitinib The CYP3A4 inducer, secobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
  • Griseofulvin The barbiturate, secobarbital, decreases the effect of griseofulvin.
  • Hydrocortisone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
  • Levonorgestrel Phenobarbital decreases the effect of levonorgestrel
  • Medroxyprogesterone Acetate The enzyme inducer, secobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
  • Megestrol acetate The enzyme inducer, secobarbital, decreases the effect of the hormone agent, megestrol.
  • Methadone The barbiturate, secobarbital, decreases the effect of methadone.
  • Metronidazole The barbiturate, secobarbital, decreases the effect of metronidazole.
  • Nifedipine The barbiturate, secobarbital, decreases the effect of the calcium channel blocker, nifedipine.
  • Norethindrone This product may cause a slight decrease of contraceptive effect
  • Oxtriphylline The barbiturate, secobarbital, decreases the effect of oxtriphylline.
  • Prednisolone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, prednisolone.
  • Prednisone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, prednisone.
  • Quinidine The anticonvulsant, secobarbital, decreases the effect of quinidine.
  • Theophylline The barbiturate, secobarbital, decreases the effect of theophylline.
  • Tretinoin The strong CYP2C8 inducer, Secobarbital, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Secobarbital is initiated, discontinued or dose changed.
  • Triamcinolone The barbiturate, secobarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Trimipramine The barbiturate, Secobarbital, may increase the metabolism and clearance of Trimipramine. Monitor for changes in the therapeutics and adverse effects of Trimipramine if Secobarbital is initiated, discontinued or dose changed. Dose adjustments of Trimipramine may be required.
  • Triprolidine The CNS depressants, Triprolidine and Secobarbital, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
  • Verapamil Secobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Secobarbital is initiated, discontinued or dose changed.
  • Warfarin Secobarbital may decrease the serum concentration of warfarin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of warfarin if secobarbital is initiated, discontinued or dose changed.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Seconal
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00418
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00430
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/63304-679-01
PharmGKB
http://www.pharmgkb.org/drug/PA164784035
Wikipedia
http://en.wikipedia.org/wiki/Secobarbital
Drugs.com
http://www.drugs.com/cdi/secobarbital.html
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