Practolol

Các tên gọi khác (6 ) :

(+-)-Practolol
1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol
4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide
N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide
Practololum
Tocris-0831

adrenergic beta 1 receptor antagonists, anti arrhythmia agents

Thuốc Gốc

Small Molecule

CAS: 6673-35-4

ATC: C07AB01

CTHH: C₁₄H₂₂N₂O₃

PTK: 266.3361

A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. [PubChem]

Nhận Dạng Quốc Tế & Đặc Tính Hóa Học

Công thức hóa học

C₁₄H₂₂N₂O₃

Phân tử khối

266.3361

Monoisotopic mass

266.16304258

InChI

InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)

InChI Key

InChIKey=DURULFYMVIFBIR-UHFFFAOYSA-N

IUPAC Name

N-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide

Traditional IUPAC Name

practolol

SMILES

CC(C)NCC(O)COC1=CC=C(NC(C)=O)C=C1

Độ tan chảy

134-136 °C

Độ hòa tan

4.90e-01 g/l

logP

0.79

logS

-2.7

pKa (strongest acidic)

14.03

pKa (Strongest Basic)

9.67

PSA

70.59 Å²

Refractivity

75.24 m³·mol^-1

Polarizability

30.39 Å³

Rotatable Bond Count

H Bond Acceptor Count

H Bond Donor Count

Physiological Charge

Number of Rings

Bioavailability

Rule of Five

true

Ghose Filter

true

caco2 Permeability

-6.05

Dược Lực Học : Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias. Beta blockers inhibit normal epinephrine-mediated sympathetic actions, but have minimal effect on resting subjects. That is, they reduce the effect of excitement/physical exertion on heart rate and force of contraction and dilation of blood vessels.

Cơ Chế Tác Dụng : A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. [PubChem] Like other beta-adrenergic antagonists, practolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, practolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure.

Độc Tính : Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.

Chỉ Định : Used in the emergency treatment of cardiac arrhythmias.

Tương Tác Thuốc :

Acetohexamide The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Chlorpropamide The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Clonidine Increased hypertension when clonidine stopped
Dihydroergotamine Ischemia with risk of gangrene
Disopyramide The beta-blocker, practolol, may increase the toxicity of disopyramide.
Epinephrine Hypertension, then bradycardia
Ergotamine Ischemia with risk of gangrene
Fenoterol Antagonism
Formoterol Antagonism
Gliclazide The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Glyburide The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Ibuprofen Risk of inhibition of renal prostaglandins
Indomethacin Risk of inhibition of renal prostaglandins
Insulin Glargine The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Methysergide Ischemia with risk of gangrene
Orciprenaline Antagonism
Oxprenolol Antagonism
Pipobroman Antagonism
Piroxicam Risk of inhibition of renal prostaglandins
Prazosin Risk of hypotension at the beginning of therapy
Repaglinide The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Terbutaline Antagonism

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB01297

KEGG Compound

http://www.genome.jp/dbget-bin/www_bget?cpd:C11696

KEGG Drug

http://www.genome.jp/dbget-bin/www_bget?drug:D05587

PharmGKB

http://www.pharmgkb.org/drug/PA164752820

Wikipedia

http://en.wikipedia.org/wiki/Practolol

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