Tìm theo
Magnesium oxide
Các tên gọi khác (1) :
  • Magmitt
antacids
Thuốc Gốc
Small Molecule
CAS: 1309-48-4
ATC: A12CC10
ĐG : Bayer Healthcare , http://www.bayerhealthcare.com
CTHH: MgO
PTK: 40.304
Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
MgO
Phân tử khối
40.304
Monoisotopic mass
39.97995652
InChI
InChI=1S/Mg.O
InChI Key
InChIKey=CPLXHLVBOLITMK-UHFFFAOYSA-N
IUPAC Name
oxomagnesium
Traditional IUPAC Name
magnesium oxide
SMILES
O=[Mg]
logP
-1.1
pKa (Strongest Basic)
13.09
PSA
17.07 Å2
Refractivity
1.44 m3·mol-1
Polarizability
2.88 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. [PubChem] The term "Milk of Magnesia" was first used to describe a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents. Magnesium supplements have also been shown to reduce platelet aggregation by inhibiting in the influx of calcium, a crucial component of platelet aggregation.
Chỉ Định : Magnesium hydroxide is used as a laxative to relieve occasional constipation (irregularity) and as an antacid to relieve indigestion, sour stomach, and heartburn.
Tương Tác Thuốc :
  • Amprenavir The antiacid decreases the absorption of amprenavir
  • Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
  • Chloroquine The antiacid decreases the absorption of chloroquine
  • Ciprofloxacin Formation of non-absorbable complexes
  • Clodronate Formation of non-absorbable complexes
  • Dapsone Formation of non-absorbable complexes
  • Delavirdine The antiacid decreases the effect of delavirdine
  • Demeclocycline Formation of non-absorbable complexes
  • Doxycycline Formation of non-absorbable complexes
  • Etidronic acid Formation of non-absorbable complexes
  • Fosamprenavir The antiacid decreases the absorption of amprenavir
  • Gatifloxacin Formation of non-absorbable complexes
  • Gemifloxacin Formation of non-absorbable complexes
  • Grepafloxacin Formation of non-absorbable complexes
  • Ibandronate Formation of non absorbable complexes
  • Indinavir The antacid decreases the absorption of indinavir
  • Itraconazole The antacid, magnesium oxide, may decrease the effect of itraconazole by decreasing its absorption.
  • Ketoconazole The antacid, magnesium oxide, may decrease the effect of ketoconazole by decreasing its absorption.
  • Levofloxacin Formation of non-absorbable complexes
  • Minocycline Formation of non-absorbable complexes
  • Moxifloxacin Formation of non-absorbable complexes
  • Norfloxacin Formation of non-absorbable complexes
  • Ofloxacin Formation of non-absorbable complexes
  • Tiludronate The divalent cation of oral Magnesium oxide may significantly decrease the absorption of Tiludronate by forming a nonabsorbable chelate. Oral dosing should be separated by at least 2 hours.
  • Trovafloxacin Magnesium may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the magnesium containing agent to minimize the interaction.
Liều Lượng & Cách Dùng : Liquid - Oral
Powder - Oral
Solution / drops - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01377
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=14792
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504815
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C12567
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01167
ChemSpider
http://www.chemspider.com/Chemical-Structure.14108.html
PharmGKB
http://www.pharmgkb.org/drug/PA450298
Wikipedia
http://en.wikipedia.org/wiki/Magnesia
Drugs.com
http://www.drugs.com/cdi/magnesium-oxide.html
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