Tìm theo
Fluphenazine
Các tên gọi khác (16 ) :
  • 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine
  • 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine
  • 10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
  • 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol
  • 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine
  • 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
  • 4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol
  • 4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
  • Flufenazina
  • Fluorfenazine
  • Fluorophenazine
  • Fluorphenazine
  • Fluphenazin
  • Fluphénazine
  • Fluphenazinum
  • Triflumethazine
Thuốc điều trị về tâm thần
Thuốc Gốc
Small Molecule
CAS: 69-23-8
ATC: N05AB02
ĐG : Amerisource Health Services Corp. , http://www.amerisourcebergen.com
CTHH: C22H26F3N3OS
PTK: 437.522
A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H26F3N3OS
Phân tử khối
437.522
Monoisotopic mass
437.174867774
InChI
InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
InChI Key
InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N
IUPAC Name
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
Traditional IUPAC Name
fluphenazine
SMILES
OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1
Độ tan chảy
224-226 (Salt)
Độ sôi
268-274 °C at 5.00E-01 mm Hg
Độ hòa tan
31.1 mg/L (at 37 °C)
logP
4.36
logS
-4.15
pKa (strongest acidic)
15.59
pKa (Strongest Basic)
8.21
PSA
29.95 Å2
Refractivity
117.27 m3·mol-1
Polarizability
44.92 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
pKa
7.9
Dược Lực Học : Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Cơ Chế Tác Dụng : A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. [PubChem] Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Chỉ Định : For management of manifestations of psychotic disorders.
Tương Tác Thuốc :
  • Amphetamine Decreased anorexic effect, may increase psychotic symptoms
  • Atomoxetine Risk of additive CNS depressant effects. Monitor for increased CNS depression during concomitant therapy.
  • Benzphetamine Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
  • Bromocriptine The phenothiazine decreases the effect of bromocriptine
  • Cisapride Increased risk of cardiotoxicity and arrhythmias
  • Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
  • Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
  • Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
  • Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
  • Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
  • Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
  • Guanethidine Fluphenazine may decrease the effect of guanethidine.
  • Levofloxacin Increased risk of cardiotoxicity and arrhythmias
  • Mazindol Decreased anorexic effect, may increase psychotic symptoms
  • Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
  • Metrizamide Increased risk of convulsions
  • Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
  • Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
  • Phentermine Decreased anorexic effect, may increase psychotic symptoms
  • Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
  • Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
  • Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Fluphenazine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
  • Terbinafine Terbinafine may reduce the metabolism and clearance of Fluphenazine. Consider alternate therapy or monitor for therapeutic/adverse effects of Fluphenazine if Terbinafine is initiated, discontinued or dose changed.
  • Terfenadine Increased risk of cardiotoxicity and arrhythmias
  • Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects. Similar pharmacologic properties thus combination therapy will worsen the severity of sedative, parkinsonian, and extrapyramidal adverse effects.
  • Trimethobenzamide Trimethobenzamide and Fluphenazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Triprolidine The antihistamine, Triprolidine, may increase the arrhythmogenic effect of the phenothiazine, Fluphenazine. Monitor for symptoms of ventricular arrhythmias. Additive anticholinergic and CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
  • Trospium Trospium and Fluphenazine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Liều Lượng & Cách Dùng : Elixir - Oral
Liquid - Intramuscular
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Sản phẩm biệt dược : Anatensol
  • Công ty :
    Sản phẩm biệt dược : Dapotum D
  • Sản phẩm biệt dược : Fludecasin
  • Công ty : Rafa
    Sản phẩm biệt dược : Fludecate
  • Sản phẩm biệt dược : Flumezin
  • Công ty : Johnson
    Sản phẩm biệt dược : Funazine
  • Công ty : Lundbeck
    Sản phẩm biệt dược : Lyogen
  • Công ty : Lundbeck
    Sản phẩm biệt dược : Lyogen Depot
  • Công ty : Lundbeck
    Sản phẩm biệt dược : Lyogen Retard
  • Công ty : Hemofarm
    Sản phẩm biệt dược : Metoten
  • Sản phẩm biệt dược : Modecate
  • Sản phẩm biệt dược : Moditen
  • Công ty : Krka
    Sản phẩm biệt dược : Moditen Depo
  • Công ty :
    Sản phẩm biệt dược : Permitil
  • Sản phẩm biệt dược : Prolixin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00623
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3372
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506645
ChemSpider
http://www.chemspider.com/Chemical-Structure.3255.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017655
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0003-0801-10
PharmGKB
http://www.pharmgkb.org/drug/PA449676
Wikipedia
http://en.wikipedia.org/wiki/Fluphenazine
RxList
http://www.rxlist.com/cgi/generic3/fluphen.htm
Drugs.com
http://www.drugs.com/cdi/fluphenazine.html
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