Tìm theo
Calcium
Thuốc Gốc
Small Molecule
CAS: 7440-70-2
ATC: D11AX03, V03AF04, C05BX01, B02BC08, B01AC08, R01AX01, N02BA15, A12AA03, A11HA31, V08AC10, A12AA11, D03AX04, A12AA06, J04AA03, A12AA30, A06AC08, A12AA02, A12AA05, A12AA09, N07BB02, A07XA03, A12AA10, V03AE01, A02AC01, A12AA04, A02AC02, A12AA08, A12AA01, A12AA20
ĐG : Atlantic Biologicals Corporation , http://www.atlanticbiologicals.com
CTHH: Ca
PTK: 40.078
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Ca
Phân tử khối
40.078
Monoisotopic mass
39.962591155
InChI
InChI=1S/Ca
InChI Key
InChIKey=OYPRJOBELJOOCE-UHFFFAOYSA-N
IUPAC Name
calcium
Traditional IUPAC Name
calcium
SMILES
[Ca]
Độ tan chảy
839°C
Độ sôi
1484°C
Độ hòa tan
0.00e+00 g/l
logP
-0.57
logS
1.08
Polarizability
1.78 Å3
Polar Surface Area (PSA)
0
Refractivity
0
Rotatable Bond Count
0
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Calcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.
Cơ Chế Tác Dụng : Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.
Dược Động Học :

▧ Route of Elimination :
The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.
Chỉ Định : Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Capsule - Oral
Liquid - Dental
Liquid - Intravenous
Liquid - Oral
Liquid - Sublingual
Paste - Dental
Powder - Oral
Powder, for solution - Oral
Solution - Intramuscular
Solution - Intravenous
Solution - Oral
Solution / drops - Oral
Syrup - Oral
Tablet - Oral
Tablet, chewable - Oral
Dữ Kiện Thương Mại
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01373
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00076
PharmGKB
http://www.pharmgkb.org/drug/PA448718
Wikipedia
http://en.wikipedia.org/wiki/Calcium
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