Bevantolol

Các tên gọi khác (6 ) :

(+-)-Bevantolol
1-((2-(3,4-Dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol
1-(3,4-Dimethoxyphenethylamino)-3-(m-tolyloxy)-2-propanol
1-(3,4-Dimethoxyphenethylamino)-3-m-tolyloxy-propan-2-ol
1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-ol
Bevantololum

adrenergic beta 1 receptor antagonists

Thuốc Gốc

Small Molecule

CAS: 59170-23-9

ATC: C07AB06

CTHH: C₂₀H₂₇NO₄

PTK: 345.4327

Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Mechanism of Action Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors.

Nhận Dạng Quốc Tế & Đặc Tính Hóa Học

Công thức hóa học

C₂₀H₂₇NO₄

Phân tử khối

345.4327

Monoisotopic mass

345.194008357

InChI

InChI=1S/C20H27NO4/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3

InChI Key

InChIKey=HXLAFSUPPDYFEO-UHFFFAOYSA-N

IUPAC Name

[2-(3,4-dimethoxyphenyl)ethyl][2-hydroxy-3-(3-methylphenoxy)propyl]amine

Traditional IUPAC Name

bevantolol

SMILES

COC1=C(OC)C=C(CCNCC(O)COC2=CC=CC(C)=C2)C=C1

Độ tan chảy

137-138 °C

Độ hòa tan

1.37e-02 g/l

logP

3.00

logS

-4.4

pKa (strongest acidic)

14.09

pKa (Strongest Basic)

9.31

PSA

59.95 Å²

Refractivity

98.54 m³·mol^-1

Polarizability

39.75 Å³

Rotatable Bond Count

H Bond Acceptor Count

H Bond Donor Count

Physiological Charge

Number of Rings

Bioavailability

Rule of Five

true

Ghose Filter

true

Dược Lực Học : Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension.

Cơ Chế Tác Dụng : Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Mechanism of Action Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors. Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors. By binding and antagonizing beta-1 receptors Bevantolol inhibits the normal normal epinephrine-mediated sympathetic actions such as increased heart rate. This has the effect of decreasing preload and blood pressure.

Chỉ Định : For the treatment of angina pectoris and hypertension.

Tương Tác Thuốc :

Chlorpropamide The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Clonidine Increased hypertension when clonidine stopped
Dihydroergotamine Ischemia with risk of gangrene
Disopyramide The beta-blocker, bevantolol, may increase the toxicity of disopyramide.
Epinephrine Hypertension, then bradycardia
Ergotamine Ischemia with risk of gangrene
Fenoterol Antagonism
Formoterol Antagonism
Gliclazide The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Glyburide The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Ibuprofen Risk of inhibition of renal prostaglandins
Indomethacin Risk of inhibition of renal prostaglandins
Insulin Glargine The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Methysergide Ischemia with risk of gangrene
Orciprenaline Antagonism
Pipobroman Antagonism
Piroxicam Risk of inhibition of renal prostaglandins
Prazosin Risk of hypotension at the beginning of therapy
Repaglinide The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Terbutaline Antagonism

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB01295

PubChem Compound

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2372

PubChem Substance

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506014

ChemSpider

http://www.chemspider.com/Chemical-Structure.2282.html

PharmGKB

http://www.pharmgkb.org/drug/PA164743236

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