Tìm theo
Trisalicylate-choline
Các tên gọi khác (1) :
  • Tricosal
Thuốc Gốc
Small Molecule
ĐG : Ivax Pharmaceuticals
CTHH: C26H29MgNO10
PTK: 539.814
Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28%.(PMID: 1728115, 1618240)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C26H29MgNO10
Phân tử khối
539.814
Monoisotopic mass
539.164188051
InChI
InChI=1S/3C7H6O3.C5H14NO.Mg/c3*8-6-4-2-1-3-5(6)7(9)10;1-6(2,3)4-5-7;/h3*1-4,8H,(H,9,10);7H,4-5H2,1-3H3;/q;;;+1;+2/p-3
InChI Key
InChIKey=FQCQGOZEWWPOKI-UHFFFAOYSA-K
IUPAC Name
magnesium(2+) ion (2-hydroxyethyl)trimethylazanium tris(2-hydroxybenzoate)
Traditional IUPAC Name
magnesium choline trisalicylate
SMILES
[Mg++].C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O
logP
1.98
pKa (strongest acidic)
2.79
pKa (Strongest Basic)
-6.3
PSA
60.36 Å2
Refractivity
46.13 m3·mol-1
Polarizability
12.38 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Dược Lực Học : Trisalicylate-choline is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate. Does not affect platelet aggregation.
Cơ Chế Tác Dụng : Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28%.(PMID: 1728115, 1618240) Inhibits prostaglandin synthesis; acts on the hypothalamus heat-regulating center to reduce fever; blocks the generation of pain impulses
Dược Động Học :

▧ Route of Elimination :
renal
Độc Tính : Salicylate intoxication, known as salicylism, may occur with large doses or extended therapy. Common symptoms of salicylism include headache, dizziness, tinnitus, hearing impairment, confusion, drowsiness, sweating, vomiting, diarrhea, and hyperventilation. A more severe degree of salicylate intoxication can lead to CNS disturbances, alteration in electrolyte balance, respiratory and metabolic acidosis, hyperthermia, and dehydration.
Chỉ Định : Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
Tương Tác Thuốc :
  • Betamethasone The corticosteroid, betamethasone, may decrease the effect of the salicylate, trisalicylate-choline.
  • Chlorpropamide The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, chlorpropamide.
  • Fludrocortisone The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, trisalicylate-choline.
  • Gliclazide The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, gliclazide.
  • Glyburide The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, glibenclamide.
  • Hydrocortisone The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, trisalicylate-choline.
  • Methazolamide The salicylate, trisalicylate-choline, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
  • Methotrexate The salicylate, trisalicylate-choline, increases the effect and toxicity of methotrexate.
  • Minocycline Formation of non-absorbable complexes
  • Prednisolone The corticosteroid, prednisolone, may decrease the effect of the salicylate, trisalicylate-choline.
  • Prednisone The corticosteroid, prednisone, may decrease the effect of the salicylate, trisalicylate-choline.
  • Probenecid The salicylate, trisalicylate-choline, decreases the uricosuric effect of probenecid.
  • Tetracycline Formation of non-absorbable complexes
  • Triamcinolone The corticosteroid, triamcinolone, may decrease the effect of the salicylate, trisalicylate-choline.
  • Warfarin The antiplatelet effects of trisalicylate-choline may increase the bleed risk associated with warfarin.
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01401
PharmGKB
http://www.pharmgkb.org/drug/PA164749164
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