Tìm theo
Triamcinolone
Các tên gọi khác (10 ) :
  • 11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
  • 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 9alpha-Fluoro-16alpha-hydroxyprednisolone
  • 9α-fluoro-16α-hydroxyprednisolone
  • Fluoxyprednisolone
  • Tiamcinolonum
  • Triamcinolona
  • Triamcinolonum
Hormon, Nội tiết tố
Thuốc Gốc
Small Molecule
CAS: 124-94-7
ATC: A01AC01, D07AB09, D07XB02, H02AB08, R01AD11, R03BA06, S01BA05, C05AA12
ĐG : AAIPharma Inc. , http://www.aaipharma.com
CTHH: C21H27FO6
PTK: 394.4339
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H27FO6
Phân tử khối
394.4339
Monoisotopic mass
394.179166801
InChI
InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
InChI Key
InChIKey=GFNANZIMVAIWHM-OBYCQNJPSA-N
IUPAC Name
(1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Traditional IUPAC Name
triamcinolone
SMILES
[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Độ tan chảy
270 °C
Độ hòa tan
80 mg/L (at 25 °C)
logP
1.16
logS
-3.69
pKa (strongest acidic)
11.75
pKa (Strongest Basic)
-3.3
PSA
115.06 Å2
Refractivity
99.38 m3·mol-1
Polarizability
39.79 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
6
H Bond Donor Count
4
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.
Cơ Chế Tác Dụng : A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739) The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Dược Động Học :
▧ Absorption :
Rapid absorption following oral administration
▧ Protein binding :
68%
▧ Metabolism :
Hepatic.
▧ Half Life :
88 minutes
Độc Tính : LD50=>500mg/kg (in rats)
Chỉ Định : For the treatment of perennial and seasonal allergic rhinitis.
Tương Tác Thuốc :
  • Acenocoumarol The corticosteroid, triamcinolone, alters the anticoagulant effect, acenocoumarol.
  • Acetylsalicylic acid The corticosteroid, triamcinolone, may decrease the effect of the salicylate, acetylsalicylic acid.
  • Ambenonium The corticosteroid, triamcinolone, may decrease the effect of the anticholinesterase, ambenonium.
  • Amobarbital The barbiturate, amobarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Anisindione The corticosteroid, triamcinolone, alters the anticoagulant effect of anisindione.
  • Aprobarbital The barbiturate, aprobarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Bismuth Subsalicylate The corticosteroid, triamcinolone, may decrease the effect of the salicylate, bismuth subsalicylate.
  • Butabarbital The barbiturate, butabarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Butalbital The barbiturate, butalbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Butethal The barbiturate, butethal, may decrease the effect of the corticosteroid, triamcinolone.
  • Dicoumarol The corticosteroid, triamcinolone, alters the anticoagulant effect of dicumarol.
  • Dihydroquinidine barbiturate The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, triamcinolone.
  • Edrophonium The corticosteroid, triamcinolone, may decrease the effect of the anticholinesterase, edrophonium.
  • Ethotoin The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, triamcinolone.
  • Fosphenytoin The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, triamcinolone.
  • Heptabarbital The barbiturate, heptabarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Hexobarbital The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Magnesium salicylate The corticosteroid, triamcinolone, may decrease the effect of magnesium salicylate.
  • Mephenytoin The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, triamcinolone.
  • Methohexital The barbiturate, methohexital, may decrease the effect of the corticosteroid, triamcinolone.
  • Methylphenobarbital The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Midodrine Increased arterial pressure
  • Neostigmine The corticosteroid, triamcinolone, may decrease the effect of the anticholinesterase, neostigmine.
  • Pentobarbital The barbiturate, pentobarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Phenobarbital The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Phenytoin The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, triamcinolone.
  • Primidone The barbiturate, primidone, may decrease the effect of the corticosteroid, triamcinolone.
  • Pyridostigmine The corticosteroid, triamcinolone, may decrease the effect of the anticholinesterase, pyridostigmine.
  • Quinidine barbiturate The barbiturate, quinidine barbiturate, may decrease the effect of the corticosteroid, triamcinolone.
  • Rifampicin The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, triamcinolone.
  • Salicylate-sodium The corticosteroid, triamcinolone, may decrease the effect of the salicylate, salicylate-sodium.
  • Salsalate The corticosteroid, triamcinolone, may decrease the effect of the salicylate, salsalate.
  • Secobarbital The barbiturate, secobarbital, may decrease the effect of the corticosteroid, triamcinolone.
  • Tacrine Tacrine and Triamcinolone may independently exacerbate muscle weakness in myasthenia gravis patients. Monitor for additive muscle weakness effects.
  • Talbutal The barbiturate, talbutal, may decrease the effect of the corticosteroid, triamcinolone.
  • Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
  • Trisalicylate-choline The corticosteroid, triamcinolone, may decrease the effect of the salicylate, trisalicylate-choline.
  • Vecuronium Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Triamcinolone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
  • Warfarin The corticosteroid, triamcinolone, alters the anticoagulant effect of warfarin.
Liều Lượng & Cách Dùng : Aerosol, metered - Nasal
Cream - Topical
Liquid - Intramuscular
Ointment - Topical
Paste - Dental
Spray - Nasal
Suspension - Intra-articular
Suspension - Intramuscular
Suspension - Intrasynovial
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    Sản phẩm biệt dược : Triaderm
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    Sản phẩm biệt dược : Trianex
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Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00620
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=31307
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507950
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00385
ChemSpider
http://www.chemspider.com/Chemical-Structure.29046.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0781-3243-75
PharmGKB
http://www.pharmgkb.org/drug/PA451749
Wikipedia
http://en.wikipedia.org/wiki/Triamcinolone
RxList
http://www.rxlist.com/cgi/generic/triamaer.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/azm1044.shtml
Drugs.com
http://www.drugs.com/cdi/triamcinolone-spray.html
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