Tìm theo
Talbutal
Các tên gọi khác (6 ) :
  • (RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione
  • 5-allyl-5-sec-butylbarbituric acid
  • Lotusate
  • sec-Butyl allyl barbituric acid
  • Talbutale
  • Talbutalum
Thuốc Gốc
Small Molecule
CAS: 115-44-6
ATC: N05CA07
CTHH: C11H16N2O3
PTK: 224.2563
Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H16N2O3
Phân tử khối
224.2563
Monoisotopic mass
224.116092388
InChI
InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16)
InChI Key
InChIKey=BJVVMKUXKQHWJK-UHFFFAOYSA-N
IUPAC Name
5-(butan-2-yl)-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
Traditional IUPAC Name
talbutal
SMILES
CCC(C)C1(CC=C)C(=O)NC(=O)NC1=O
Độ tan chảy
109 °C
Độ hòa tan
1810 mg/L at 25 °C
logP
1.47
logS
-2
pKa (strongest acidic)
8.48
PSA
75.27 Å2
Refractivity
58.05 m3·mol-1
Polarizability
22.48 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
7.79 (at 25 °C)
Dược Lực Học : Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.
Cơ Chế Tác Dụng : Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S. Talbutal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Độc Tính : Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension, and shock.
Chỉ Định : For use as a sedative and hypnotic.
Tương Tác Thuốc :
  • Aminophylline The barbiturate, talbutal, decreases the effect of aminophylline.
  • Betamethasone The barbiturate, talbutal, may decrease the effect of the corticosteroid, betamethasone.
  • Clomifene The enzyme inducer, talbutal, decreases the effect of the hormone agent, clomifene.
  • Conjugated Estrogens The enzyme inducer, talbutal, decreases the effect of the hormone agent, conjugated estrogens.
  • Cyclosporine The sulfonamide decreases the effect of cyclosporine
  • Dexamethasone The barbiturate, talbutal, may decrease the effect of the corticosteroid, dexamethasone.
  • Diethylstilbestrol The enzyme inducer, talbutal, decreases the effect of the hormone agent, diethylstilbestrol.
  • Doxycycline The anticonvulsant, talbutal, decreases the effect of doxycycline.
  • Estradiol The enzyme inducer, talbutal, decreases the effect of the hormone agent, estradiol.
  • Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
  • Felodipine The barbiturate, talbutal, decreases the effect of felodipine.
  • Fludrocortisone The barbiturate, talbutal, may decrease the effect of the corticosteroid, fludrocortisone.
  • Folic Acid Folic acid decreases the effect of anticonvulsant, talbutal.
  • Gefitinib The CYP3A4 inducer, talbutal, may decrease the serum concentration and therapeutic effects of gefitinib.
  • Griseofulvin The barbiturate, talbutal, decreases the effect of griseofulvin.
  • Hydrocortisone The barbiturate, talbutal, may decrease the effect of the corticosteroid, hydrocortisone.
  • Levonorgestrel Phenobarbital decreases the effect of levonorgestrel
  • Medroxyprogesterone Acetate The enzyme inducer, talbutal, decreases the effect of the hormone agent, medroxyprogesterone.
  • Megestrol acetate The enzyme inducer, talbutal, decreases the effect of the hormone agent, megestrol.
  • Methadone The barbiturate, talbutal, decreases the effect of methadone.
  • Metronidazole The barbiturate, talbutal, decreases the effect of metronidazole.
  • Nifedipine The barbiturate, talbutal, decreases the effect of the calcium channel blocker, nifedipine.
  • Norethindrone This product may cause a slight decrease of contraceptive effect
  • Oxtriphylline The barbiturate, talbutal, decreases the effect of oxtriphylline.
  • Prednisolone The barbiturate, talbutal, may decrease the effect of the corticosteroid, prednisolone.
  • Prednisone The barbiturate, talbutal, may decrease the effect of the corticosteroid, prednisone.
  • Quinidine The anticonvulsant, talbutal, decreases the effect of quinidine.
  • Theophylline The barbiturate, talbutal, decreases the effect of theophylline.
  • Triamcinolone The barbiturate, talbutal, may decrease the effect of the corticosteroid, triamcinolone.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00306
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D06887
PharmGKB
http://www.pharmgkb.org/drug/PA164779051
Wikipedia
http://en.wikipedia.org/wiki/Talbutal
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