Tìm theo
Salicylate-sodium
Các tên gọi khác (1) :
  • Salsonin
anti inflammatory agents non steroidal, salicylates
Thuốc Gốc
Small Molecule
ATC: D01AE12, S01BC08
ĐG : J T Baker , http://www.jtbaker.com
CTHH: C7H5NaO3
PTK: 160.1026
Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID) and induces apoptosis in cancer cells. It is also potential replacement for aspirin for people sensitive to it.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C7H5NaO3
Phân tử khối
160.1026
Monoisotopic mass
160.013638701
InChI
InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChI Key
InChIKey=ABBQHOQBGMUPJH-UHFFFAOYSA-M
IUPAC Name
sodium 2-hydroxybenzoate
Traditional IUPAC Name
sodium salicylate
SMILES
[Na+].OC1=CC=CC=C1C([O-])=O
Độ hòa tan
4.81e+01 g/l
logP
1.98
logS
-0.52
pKa (strongest acidic)
2.79
pKa (Strongest Basic)
-6.3
PSA
60.36 Å2
Refractivity
46.13 m3·mol-1
Polarizability
12.38 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Non-steroidal anti-inflammatory drugs such as Salicylate-sodium work by inhibiting the enzyme cyclooxygenase (COX), which converts arachidonic acid to prostaglandin H2 (PGH2). PGH2, in turn, is converted by other enzymes to several other prostaglandins (which are mediators of pain, inflammation, and fever)
Cơ Chế Tác Dụng : Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID) and induces apoptosis in cancer cells. It is also potential replacement for aspirin for people sensitive to it. Salicylate-sodium is considered a non-selective COX inhibitor—that is, it inhibits two isoforms of cyclooxygenase, COX-1 and COX-2. The analgesic, antipyretic, and anti-inflammatory activity of NSAIDs appears to be achieved mainly through inhibition of COX-2, whereas inhibition of COX-1 would be responsible for unwanted effects on platelet aggregation and the gastrointestinal tract. However, the role of the individual COX isoforms in the analgesic, anti-inflammatory, and gastric damage effects of NSAIDs is uncertain and different compounds cause different degrees of analgesia and gastric damage. Salicylate-sodium directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms.
Chỉ Định : It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID)
Tương Tác Thuốc :
  • Betamethasone The corticosteroid, betamethasone, may decrease the effect of the salicylate, salicylate-sodium.
  • Fludrocortisone The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, salicylate-sodium.
  • Gliclazide The salicylate, salicylate-sodium, increases the effect of the sulfonylurea, gliclazide.
  • Glyburide The salicylate, salicylate-sodium, increases the effect of the sulfonylurea, glibenclamide.
  • Hydrocortisone The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, salicylate-sodium.
  • Methazolamide The salicylate, salicylate-sodium, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
  • Methotrexate The salicylate, salicylate-sodium, increases the effect and toxicity of methotrexate.
  • Prednisolone The corticosteroid, prednisolone, may decrease the effect of the salicylate, salicylate-sodium.
  • Prednisone The corticosteroid, prednisone, may decrease the effect of the salicylate, salicylate-sodium.
  • Probenecid The salicylate, salicylate-sodium, decreases the uricosuric effect of probenecid.
  • Sulindac Risk of additive toxicity (e.g. bleed risk). Salicylate-sodium may decrease the serum concentration of sulindac. Consider alternate therapy or monitor for changes in the therapeutic effects of sulindac and adverse effects of both agents if the interacting agent is initiated, discontinued or dose changed.
  • Triamcinolone The corticosteroid, triamcinolone, may decrease the effect of the salicylate, salicylate-sodium.
  • Warfarin The antiplatelet effects of sodium salicylate may increase the bleed risk associated with warfarin.
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01398
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00566
PharmGKB
http://www.pharmgkb.org/drug/PA451428
Wikipedia
http://en.wikipedia.org/wiki/Sodium_salicylate
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