Tìm theo
Pseudoephedrine
Các tên gọi khác (17 ) :
  • (+)-(1S,2S)-Pseudoephedrine
  • (+)-Pseudoephedrine
  • (+)-Psi-ephedrine
  • (+)-threo-Ephedrine
  • D-Isoephedrine
  • D-Pseudoephedrine
  • D-Psi-2-methylamino-1-phenyl-1-propanol
  • D-Psi-ephedrine
  • Isoephedrine
  • L-(+)-Pseudoephedrine
  • L(+)-Psi-ephedrine
  • Pseudoefedrina
  • Pseudoephedrine
  • Pseudoephedrinum
  • Psi-ephedrin
  • Psi-ephedrine
  • trans-Ephedrine
Thuốc dùng điều trị mắt, tai mũi họng
Thuốc Gốc
Small Molecule
CAS: 90-82-4
ATC: R01BA02
ĐG : Actavis Group , http://www.actavis.com
CTHH: C10H15NO
PTK: 165.2322
An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H15NO
Phân tử khối
165.2322
Monoisotopic mass
165.115364107
InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
InChI Key
InChIKey=KWGRBVOPPLSCSI-WCBMZHEXSA-N
IUPAC Name
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
Traditional IUPAC Name
pseudoephedrine
SMILES
CN[C@@H](C)[C@@H](O)C1=CC=CC=C1
Độ tan chảy
119 °C
Độ hòa tan
7 mg/L
logP
0.89
logS
-1.3
pKa (strongest acidic)
13.89
pKa (Strongest Basic)
9.52
PSA
32.26 Å2
Refractivity
49.69 m3·mol-1
Polarizability
18.83 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
10.3 (at 0 °C)
Dược Lực Học : Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).
Cơ Chế Tác Dụng : An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem] Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors.
Dược Động Học :
▧ Absorption :
Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
▧ Protein binding :
Pseudoephedrine does not bind to human plasma proteins over the concentration range of 50 to 2000 ng/mL
▧ Metabolism :
Hepatic.
▧ Half Life :
9-16 hours
Độc Tính : Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.
Chỉ Định : For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
Tương Tác Thuốc :
  • Alseroxylon Increased arterial pressure
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of pseudoephedrine.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of pseudoephedrine.
  • Bromocriptine The sympathomimetic, pseudoephedrine, increases the toxicity of bromocriptine.
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of pseudoephedrine.
  • Deserpidine Increased arterial pressure
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of pseudoephedrine.
  • Desvenlafaxine Desvenlafaxine may increase the tachycardic and vasopressor effects of pseudoephedrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of pseudoephedrine.
  • Guanethidine Pseudoephedrine may decrease the effect of guanethidine.
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of pseudoephedrine.
  • Iobenguane Sympathomimetic that increase chances of producing a false negative imaging result
  • Isocarboxazid Increased arterial pressure
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of pseudoephedrine.
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of pseudoephedrine.
  • Pargyline Increased arterial pressure
  • Phenelzine Increased arterial pressure
  • Protriptyline The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of pseudoephedrine.
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
  • Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the vasopressor effect of Pseudoephedrine. Concomitant therapy should be avoided.
  • Trimipramine The tricyclic antidepressant, trimipramine, increases the sympathomimetic effect of pseudoephedrine.
  • Venlafaxine Venlafaxine may increase the tachycardic and vasopressor effects of Pseudoephedrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Liều Lượng & Cách Dùng : Liquid - Oral
Syrup - Oral
Tablet - Oral
Tablet, extended release - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
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    Sản phẩm biệt dược : Decofed
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    Sản phẩm biệt dược : Dimetapp Decongestant
  • Công ty :
    Sản phẩm biệt dược : Eltor 120
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    Sản phẩm biệt dược : Genaphed
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    Sản phẩm biệt dược : Maxenal
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    Sản phẩm biệt dược : Myfedrine
  • Công ty :
    Sản phẩm biệt dược : Novafed
  • Công ty :
    Sản phẩm biệt dược : Robidrine
  • Công ty :
    Sản phẩm biệt dược : Sudafed Decongestant
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00852
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7028
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508190
ChemSpider
http://www.chemspider.com/Chemical-Structure.6761.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/11822-0054-6
PharmGKB
http://www.pharmgkb.org/drug/PA451170
Wikipedia
http://en.wikipedia.org/wiki/Pseudoephedrine
RxList
http://www.rxlist.com/cgi/generic/sudafed.htm
Drugs.com
http://www.drugs.com/pseudoephedrine.html
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