Tìm theo
Prazepam
Các tên gọi khác (2) :
  • Centrax
  • Prazepamum
Thuốc chống lo âu, hoảng sợ
Thuốc Gốc
Small Molecule
CAS: 2955-38-6
ATC: N05BA11
ĐG : Physicians Total Care Inc. , http://www.physicianstotalcare.com
CTHH: C19H17ClN2O
PTK: 324.804
Prazepam is a benzodiazepine that is used in the treatment of anxiety disorders. It is a schedule IV drug in the U.S.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H17ClN2O
Phân tử khối
324.804
Monoisotopic mass
324.102940883
InChI
InChI=1S/C19H17ClN2O/c20-15-8-9-17-16(10-15)19(14-4-2-1-3-5-14)21-11-18(23)22(17)12-13-6-7-13/h1-5,8-10,13H,6-7,11-12H2
InChI Key
InChIKey=MWQCHHACWWAQLJ-UHFFFAOYSA-N
IUPAC Name
7-chloro-1-(cyclopropylmethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Traditional IUPAC Name
prazepam
SMILES
ClC1=CC2=C(C=C1)N(CC1CC1)C(=O)CN=C2C1=CC=CC=C1
Độ tan chảy
145-146 °C
Độ hòa tan
3.99e-03 g/l
logP
3.73
logS
-4.9
pKa (Strongest Basic)
3.06
PSA
32.67 Å2
Refractivity
91.75 m3·mol-1
Polarizability
34.77 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Prazepam is a benzodiazepine derivative drug. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Benzodiazepines may be habit-forming (causing mental or physical dependence), especially when taken for a long time or in high doses.
Cơ Chế Tác Dụng : Prazepam is a benzodiazepine that is used in the treatment of anxiety disorders. It is a schedule IV drug in the U.S. Prazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.
Dược Động Học :

▧ Metabolism :
Hepatic.
▧ Half Life :
36-200 hours
Độc Tính : Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Chỉ Định : For the treatment of anxiety disorders.
Tương Tác Thuốc :
  • Cimetidine Cimetidine may increase the effect of the benzodiazepine, prazepam.
  • Clozapine Increased risk of toxicity
  • Indinavir The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, prazepam.
  • Nelfinavir The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, prazepam.
  • Omeprazole Omeprazole may increase the effect of the benzodiazepine, prazepam.
  • Tipranavir Tipranavir may decrease the metabolism and clearance of Prazepam. Consider alternate therapy or monitor for Prazepam toxic effects if Tipranavir is initiated or dose increased.
  • Triprolidine The CNS depressants, Triprolidine and Prazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
  • Voriconazole Voriconazole may increase the serum concentration of prazepam by decreasing its metabolism. Monitor for prazepam toxicity if voriconazole is initiated or dose increased.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Doral 7.5 mg tablet
    Giá bán buôn : USD >3.37
    Đơn vị tính : tablet
  • Biệt dược thương mại : Doral 15 mg tablet
    Giá bán buôn : USD >3.41
    Đơn vị tính : tablet
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Centrax
  • Công ty :
    Sản phẩm biệt dược : Demetrin
  • Công ty :
    Sản phẩm biệt dược : Lysanxia
  • Công ty :
    Sản phẩm biệt dược : Sedapran
  • Công ty :
    Sản phẩm biệt dược : Trepidan
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01588
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4890
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505417
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07366
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00470
ChemSpider
http://www.chemspider.com/Chemical-Structure.4721.html
PharmGKB
http://www.pharmgkb.org/drug/PA164776668
Wikipedia
http://en.wikipedia.org/wiki/Prazepam
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