Tìm theo
Norepinephrine
Các tên gọi khác (14 ) :
  • (-)-Arterenol
  • (-)-Noradrenaline
  • (-)-Norepinephrine
  • (R)-(-)-Norepinephrine
  • (R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol
  • (R)-Norepinephrine
  • 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
  • Arterenol
  • L-noradrenaline
  • L-Norepinephrine
  • Noradrenaline
  • Norepinefrina
  • Norepinephrine
  • Norepinephrinum
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 51-41-2
ATC: C01CA03
ĐG : Bedford Labs , http://www.bedfordlabs.com
CTHH: C8H11NO3
PTK: 169.1778
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H11NO3
Phân tử khối
169.1778
Monoisotopic mass
169.073893223
InChI
InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
InChI Key
InChIKey=SFLSHLFXELFNJZ-QMMMGPOBSA-N
IUPAC Name
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Traditional IUPAC Name
norepinephrine
SMILES
NC[C@H](O)C1=CC(O)=C(O)C=C1
Độ tan chảy
217 dec °C
Độ hòa tan
1.25e+01 g/l
logP
-1.24
logS
-1.1
pKa (strongest acidic)
9.5
pKa (Strongest Basic)
8.85
PSA
86.71 Å2
Refractivity
44.46 m3·mol-1
Polarizability
16.96 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
8.58
Dược Lực Học : Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance.
Cơ Chế Tác Dụng : Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. [PubChem] Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it's activity at the beta-adrenergic receptors.
Độc Tính : In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
Chỉ Định : Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Tương Tác Thuốc :
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of norepinephrine.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of norepinephrine.
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of norepinephrine.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of norepinephrine.
  • Desvenlafaxine Desvenlafaxine may increase the tachycardic and vasopressor effects of norepinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of norepinephrine.
  • Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, norepinephrine.
  • Guanethidine Norepinephrine may decrease the effect of guanethidine.
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of norepinephrine.
  • Isocarboxazid Increased arterial pressure
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of norepinephrine.
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of norepinephrine.
  • Phenelzine Increased arterial pressure
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
  • Trimipramine Trimipramine may increase the vasopressor effect of the direct-acting alpha-/beta-agonist, Norepinephrine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
  • Venlafaxine Venlafaxine may increase the tachycardic and vasopressor effects of Norepinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Liều Lượng & Cách Dùng : Insert, extended release - Intrauterine
Liquid - Intravenous
Solution - Intravenous
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Levophed
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00368
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=439260
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506201
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00547
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00076
ChemSpider
http://www.chemspider.com/Chemical-Structure.388394.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0409-3375-04
PharmGKB
http://www.pharmgkb.org/drug/PA450649
Wikipedia
http://en.wikipedia.org/wiki/Norepinephrine
RxList
http://www.rxlist.com/cgi/generic/norepinephrine.htm
Drugs.com
http://www.drugs.com/mtm/norepinephrine.html
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