Tìm theo
Glucosamine
Các tên gọi khác (3) :
  • 2-Amino-2-deoxy-D-glucose
  • Chitosamine
  • D-Glucosamine
Thuốc giảm đau, hạ sốt, chống viêm không steroid, điều trị Gút và các bệnh xương khớp
Thuốc Gốc
Small Molecule
CAS: 3416-24-8
ĐG : 21st Century Healthcare Inc. , http://www.21stcenturyvitamins.com
CTHH: C6H13NO5
PTK: 179.1711
Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H13NO5
Phân tử khối
179.1711
Monoisotopic mass
179.079372531
InChI
InChI=1S/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6?/m1/s1
InChI Key
InChIKey=MSWZFWKMSRAUBD-IVMDWMLBSA-N
IUPAC Name
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
Traditional IUPAC Name
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
SMILES
N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
Độ tan chảy
88 °C
Độ hòa tan
5.51e+02 g/l
logP
-3
logS
0.49
pKa (strongest acidic)
11.73
pKa (Strongest Basic)
8.23
PSA
116.17 Å2
Refractivity
37.58 m3·mol-1
Polarizability
16.87 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
6
H Bond Donor Count
5
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Osteoarthritis is characterized by the progressive degeneration of cartilage glycosaminoglycans. The formation of glucosamine is the rate limiting step in glycosaminoglycans synthesis thus the addition is glucosamine, would in theory provide a building block towards the synthesis of glycosaminoglycans and thus slow down the progression of osteoarthritis. Thus far however, the results have not been conclusive.
Cơ Chế Tác Dụng : Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness with more recent studies showing limited to no clinical benefit of use. In the United States, glucosamine is not approved by the Food and Drug Administration for medical use in humans. Since glucosamine is classified as a dietary supplement, safety and formulation are solely the responsibility of the manufacturer; evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition.
Độc Tính : Adverse effects are generally mild: itching, diarrhea, heartburn, nausea and vomiting.
Chỉ Định : Glucosamine is usually used in the treatment of osteoarthritis, although its efficacy is still in question.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Tablet - Oral - 1.5
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01296
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=439213
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506420
ChemSpider
http://www.chemspider.com/Chemical-Structure.388352.html
PharmGKB
http://www.pharmgkb.org/drug/PA164747613
Wikipedia
http://en.wikipedia.org/wiki/Glucosamine
Drugs.com
http://www.drugs.com/cdi/glucosamine.html
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