Tìm theo
Enoxacin
Các tên gọi khác (7 ) :
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
  • 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
  • Enoxacin
  • Enoxacina
  • Énoxacine
  • Enoxacino
  • Enoxacinum
Thuốc Gốc
Small Molecule
CAS: 74011-58-8
ATC: J01MA04, J01MA19
CTHH: C15H17FN4O3
PTK: 320.3189
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H17FN4O3
Phân tử khối
320.3189
Monoisotopic mass
320.128468635
InChI
InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
InChI Key
InChIKey=IDYZIJYBMGIQMJ-UHFFFAOYSA-N
IUPAC Name
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Traditional IUPAC Name
enoxacin
SMILES
CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(N=C12)N1CCNCC1
Độ tan chảy
220-224 °C
Độ hòa tan
3.43 g/L
logP
-0.20
logS
-2.5
pKa (strongest acidic)
5.5
pKa (Strongest Basic)
8.59
PSA
85.77 Å2
Refractivity
83.95 m3·mol-1
Polarizability
31.63 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
7
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Enoxacin is a quinolone/fluoroquinolone antibiotic. Enoxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Enoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Enoxacin may be active against pathogens resistant to drugs that act by different mechanisms.
Cơ Chế Tác Dụng : A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. [PubChem] Enoxacin exerts its bactericidal action via the inhibition of the essential bacterial enzyme DNA gyrase (DNA Topoisomerase II).
Dược Động Học :
▧ Absorption :
Rapidly absorbed following oral administration, with an absolute oral bioavailability of approximately 90%.
▧ Protein binding :
Enoxacin is approximately 40% bound to plasma proteins in healthy subjects and is approximately 14% bound to plasma proteins in patients with impaired renal function.
▧ Metabolism :
Hepatic. Some isozymes of the cytochrome P-450 hepatic microsomal enzyme system are inhibited by enoxacin. After a single dose, greater than 40% was recovered in urine by 48 hours as unchanged drug.
▧ Half Life :
Plasma half-life is 3 to 6 hours.
Chỉ Định : For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria gonorrhoeae, (2) uncomplicated urinary tract infections (cystitis) due to Escherichia coli, Staphylococcus epidermidis, or Staphylococcus saprophyticus, and (3) complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus epidermidis, or Enterobacter cloacae.
Tương Tác Thuốc :
  • Aminophylline Enoxacin may increase the effect of aminophylline.
  • Calcium Formation of non-absorbable complexes
  • Cimetidine Cimetidine may decrease the absorption of enoxacin.
  • Eltrombopag Affects hepatic enzyme CYP1A2 metabolism and may increase the level of eltrombopag.
  • Esomeprazole Esomeprazole may decrease the absorption of enoxacin.
  • Famotidine Famotidine may decrease the absorption of enoxacin.
  • Iron Dextran Formation of non-absorbable complexes
  • Lansoprazole Lansoprazole may decrease the absorption of enoxacin.
  • Magnesium Formation of non-absorbable complexes
  • Nizatidine Nizatidine may decrease the absorption of enoxacin.
  • Omeprazole Omeprazole may decrease the absorption of enoxacin.
  • Oxtriphylline Enoxacin may increase the effect of oxtriphylline.
  • Pantoprazole Pantoprazole may decrease the absorption of enoxacin.
  • Rabeprazole Rabeprazole may decrease the absorption of enoxacin.
  • Ramelteon Enoxacin increases levels/toxicity of ramelteon
  • Theophylline Enoxacin may increase the effect of theophylline.
Liều Lượng & Cách Dùng : Tablet, film coated - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Almitil
  • Công ty :
    Sản phẩm biệt dược : Bactidan
  • Công ty :
    Sản phẩm biệt dược : Comprecin
  • Công ty :
    Sản phẩm biệt dược : Enoksetin
  • Công ty :
    Sản phẩm biệt dược : Enoxen
  • Công ty :
    Sản phẩm biệt dược : Enoxin
  • Công ty : Pierre Fabre
    Sản phẩm biệt dược : Enoxor
  • Công ty :
    Sản phẩm biệt dược : Enoxor
  • Công ty :
    Sản phẩm biệt dược : Enroxil
  • Công ty :
    Sản phẩm biệt dược : Flumark
  • Công ty :
    Sản phẩm biệt dược : Gyramid
  • Công ty :
    Sản phẩm biệt dược : Penetrex
  • Công ty :
    Sản phẩm biệt dược : Vinone
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00467
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3229
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507505
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06979
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00310
ChemSpider
http://www.chemspider.com/Chemical-Structure.3116.html
PharmGKB
http://www.pharmgkb.org/drug/PA449462
Wikipedia
http://en.wikipedia.org/wiki/Enoxacin
RxList
http://www.rxlist.com/cgi/generic2/enoxacin.htm
Drugs.com
http://www.drugs.com/mtm/enoxacin.html
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