Tìm theo
Butethal
Các tên gọi khác (4 ) :
  • Butethal
  • Butobarbital
  • Butobarbitone
  • Neonal
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 77-28-1
CTHH: C10H16N2O3
PTK: 212.2456
Butethal is a sedative and a hypnotic drug.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H16N2O3
Phân tử khối
212.2456
Monoisotopic mass
212.116092388
InChI
InChI=1S/C10H16N2O3/c1-3-5-6-10(4-2)7(13)11-9(15)12-8(10)14/h3-6H2,1-2H3,(H2,11,12,13,14,15)
InChI Key
InChIKey=STDBAQMTJLUMFW-UHFFFAOYSA-N
IUPAC Name
5-butyl-5-ethyl-1,3-diazinane-2,4,6-trione
Traditional IUPAC Name
butethal
SMILES
CCCCC1(CC)C(=O)NC(=O)NC1=O
Độ tan chảy
128.5 °C
Độ hòa tan
4880 mg/L (at 25 °C)
logP
1.73
logS
-1.64
pKa (strongest acidic)
8.48
PSA
75.27 Å2
Refractivity
53.45 m3·mol-1
Polarizability
21.62 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
7.86
Dược Lực Học : Butethal (also known as butobarbitone and butobarbital) belongs to a group of medicines called the barbiturates. It is thought to act on receptors in the brain (GABA receptors) causing the release of the chemical GABA. This chemical inhibits certain areas of the brain resulting in sleepiness.
Cơ Chế Tác Dụng : Butethal is a sedative and a hypnotic drug. Butethal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following oral administration.
▧ Metabolism :
Hepatic.
▧ Half Life :
37 hours
Độc Tính : Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).
Chỉ Định : For the treatment of insomnia.
Tương Tác Thuốc :
  • Aminophylline The barbiturate, butethal, decreases the effect of aminophylline.
  • Betamethasone The barbiturate, butethal, may decrease the effect of the corticosteroid, betamethasone.
  • Clomifene The enzyme inducer, butethal, decreases the effect of the hormone agent, clomifene.
  • Conjugated Estrogens The enzyme inducer, butethal, decreases the effect of the hormone agent, conjugated estrogens.
  • Cyclosporine The barbiturate, butethal, increases the effect of cyclosporine.
  • Dexamethasone The barbiturate, butethal, may decrease the effect of the corticosteroid, dexamethasone.
  • Diethylstilbestrol The enzyme inducer, butethal, decreases the effect of the hormone agent, diethylstilbestrol.
  • Doxycycline The anticonvulsant, butethal, decreases the effect of doxycycline.
  • Estradiol The enzyme inducer, butethal, decreases the effect of the hormone agent, estradiol.
  • Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
  • Felodipine The barbiturate, butethal, decreases the effect of felodipine.
  • Fludrocortisone The barbiturate, butethal, may decrease the effect of the corticosteroid, fludrocortisone.
  • Folic Acid Folic acid decreases the effect of anticonvulsant, butethal.
  • Gefitinib The CYP3A4 inducer, butethal, may decrease the serum concentration and therapeutic effects of gefitinib.
  • Griseofulvin The barbiturate, butethal, decreases the effect of griseofulvin.
  • Hydrocortisone The barbiturate, butethal, may decrease the effect of the corticosteroid, hydrocortisone.
  • Levonorgestrel Phenobarbital decreases the effect of levonorgestrel
  • Medroxyprogesterone Acetate The enzyme inducer, butethal, decreases the effect of the hormone agent, medroxyprogesterone.
  • Megestrol acetate The enzyme inducer, butethal, decreases the effect of the hormone agent, megestrol.
  • Methadone The barbiturate, butethal, decreases the effect of methadone.
  • Metronidazole The barbiturate, butethal, decreases the effect of metronidazole.
  • Nifedipine The barbiturate, butethal, decreases the effect of the calcium channel blocker, nifedipine.
  • Norethindrone This product may cause a slight decrease of contraceptive effect
  • Oxtriphylline The barbiturate, butethal, decreases the effect of oxtriphylline.
  • Prednisolone The barbiturate, butethal, may decrease the effect of the corticosteroid, prednisolone.
  • Prednisone The barbiturate, butethal, may decrease the effect of the corticosteroid, prednisone.
  • Quinidine The anticonvulsant, butethal, decreases the effect of quinidine.
  • Theophylline The barbiturate, butethal, decreases the effect of theophylline.
  • Triamcinolone The barbiturate, butethal, may decrease the effect of the corticosteroid, triamcinolone.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Neonal
  • Công ty :
    Sản phẩm biệt dược : Soneryl
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01353
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6473
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508397
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02618
ChemSpider
http://www.chemspider.com/Chemical-Structure.6229.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748035
Wikipedia
http://en.wikipedia.org/wiki/Butobarbital
... loading
... loading