Tìm theo
Vitamin C
Các tên gọi khác (16 ) :
  • Acide ascorbique
  • Acido ascorbico
  • Acidum ascorbicum
  • Acidum ascorbinicum
  • Ascoltin
  • Ascorbate
  • Ascorbic Acid
  • Ascorbicap
  • Ascorbinsaeure
  • e 300
  • e-300
  • e300
  • L-(+)-ascorbic acid
  • L-Ascorbate
  • L-Ascorbic Acid
  • Vitamin C
Khoáng chất và Vitamin
Thuốc Gốc
Small Molecule
CAS: 50-81-7
ATC: S01XA15, G01AD03, A11GA01
ĐG : American Regent , http://www.americanregent.com
CTHH: C6H8O6
PTK: 176.1241
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H8O6
Phân tử khối
176.1241
Monoisotopic mass
176.032087988
InChI
InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChI Key
InChIKey=CIWBSHSKHKDKBQ-JLAZNSOCSA-N
IUPAC Name
(5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one
Traditional IUPAC Name
vitamin C
SMILES
[H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO
Độ tan chảy
191 dec °C
Độ hòa tan
4E+005 mg/L (at 40 °C)
logP
-1.85
logS
0.14
pKa (strongest acidic)
4.36
pKa (Strongest Basic)
-3
PSA
107.22 Å2
Refractivity
37.03 m3·mol-1
Polarizability
14.93 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
4
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
4.7 (at 10 °C)
Dược Lực Học : Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses the symptoms of ascorbic acid deficiency.
Cơ Chế Tác Dụng : A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. [PubChem] In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration.
Dược Động Học :
▧ Absorption :
70% to 90%
▧ Protein binding :
25%
▧ Metabolism :
Hepatic. Ascorbic acid is reversibly oxidised (by removal of the hydrogen from the enediol group of ascorbic acid) to dehydroascorbic acid. The two forms found in body fluids are physiologically active. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.
▧ Half Life :
16 days (3.4 hours in people who have excess levels of vitamin C)
Chỉ Định : Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
Tương Tác Thuốc :
  • Deferoxamine Vitamin C may increase the adverse effects of deferoxamine. Transient deterioration of left ventricular function has been observed during concomitant therapy. Use caution during concomitant therapy.
  • Indinavir Vitamin C decreases indinavir levels
Liều Lượng & Cách Dùng : Bar, chewable - Oral
Capsule - Oral
Capsule, extended release - Oral
Granule - Oral
Liquid - Intravenous
Liquid - Oral
Lozenge - Oral
Powder - Oral
Powder, for solution - Oral
Solution - Intramuscular
Solution - Intravenous
Solution - Oral
Solution / drops - Oral
Tablet - Oral
Tablet, chewable - Oral
Tablet, effervescent - Oral
Tablet, extended release - Oral
Wafer - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ascoltin
  • Công ty :
    Sản phẩm biệt dược : Ascorbicap
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00126
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00072
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00018
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090256
PharmGKB
http://www.pharmgkb.org/drug/PA451898
Wikipedia
http://en.wikipedia.org/wiki/Vitamin_C
RxList
http://www.rxlist.com/cgi/generic3/vitamc.htm
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0264.shtml
Drugs.com
http://www.drugs.com/cdi/ascorbic-acid.html
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