Tìm theo
Somatropin recombinant
Các tên gọi khác (7 ) :
  • GH
  • GH-N
  • Growth hormone
  • Growth hormone 1
  • Pituitary growth hormone
  • Somatotropin precursor
  • Somatropin
Hormon thượng thận và những chất tổng hợp thay thế
Thuốc Gốc
Biotech
CAS: 12629-01-5
ATC: H01AC01
ĐG : Bio Technology General Ltd.
CTHH: C990H1532N262O300S7
PTK: 22129.0000
Recombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C990H1532N262O300S7
Phân tử khối
22129.0000
Độ tan chảy
76 °C at pH 3.5
Độ kỵ nước
-0.411
Điểm đẳng điện tích
5.27
Dược Lực Học : Used in the treatment of dwarfism and growth failure, growth hormone (hGH) stimulates skeletal growth in pediatric patients with growth failure due to a lack of adequate secretion of endogenous GH. Skeletal growth is accomplished at the epiphyseal plates at the ends of a growing bone. Growth and metabolism of epiphyseal plate cells are directly stimulated by GH and one of its mediators, IGF-I (insulin-like growth factor).
Cơ Chế Tác Dụng : Recombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli hGH binds to the human growth hormone receptor (GHR). Upon binding, hGH causes dimerization of GHR, activation of the GHR-associated JAK2 tyrosine kinase, and tyrosyl phosphorylation of both JAK2 and GHR. These events recruit and/or activate a variety of signaling molecules, including MAP kinases, insulin receptor substrates, phosphatidylinositol 3' phosphate kinase, diacylglycerol, protein kinase C, intracellular calcium, and Stat transcription factors. These signaling molecules contribute to the GH-induced changes in enzymatic activity, transport function, and gene expression that ultimately culminate in changes in growth and metabolism.
Dược Động Học :

▧ Route of Elimination :
Although calcium excretion in the urine is increased, there is a simultaneous increase in calcium absorption from the intestine. Somatropin stimulates the synthesis of chondroitin sulfate and collagen, and increases the urinary excretion of hydroxyproline.
▧ Clearance :
* 2.3 +/- 1.8 mL/min/kg [GHD patients (IV 33 ng/kg/min)]
Chỉ Định : For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss
Tương Tác Thuốc :
  • Acarbose Somatropin may antagonize the hypoglycemic effect of acarbose. Monitor for changes in fasting and postprandial blood sugars.
  • Chlorpropamide Somatropin may antagonize the hypoglycemic effect of chlorpropamide. Monitor for changes in fasting and postprandial blood sugars.
  • Exenatide Somatropin may antagonize the hypoglycemic effect of exenatide. Monitor for changes in fasting and postprandial blood sugars.
  • Gliclazide Somatropin may antagonize the hypoglycemic effect of gliclazide. Monitor for changes in fasting and postprandial blood sugars.
  • Glimepiride Somatropin may antagonize the hypoglycemic effect of glimepiride. Monitor for changes in fasting and postprandial blood sugars.
  • Glipizide Somatropin may antagonize the hypoglycemic effect of glipizide. Monitor for changes in fasting and postprandial blood sugars.
  • Glyburide Somatropin may antagonize the hypoglycemic effect of glibenclamide. Monitor for changes in fasting and postprandial blood sugars.
  • Insulin Aspart Somatropin may antagonize the hypoglycemic effect of insulin aspart. Monitor for changes in fasting and postprandial blood sugars.
  • Insulin Detemir Somatropin may antagonize the hypoglycemic effect of insulin detemir. Monitor for changes in fasting and postprandial blood sugars.
  • Insulin Glargine Somatropin may antagonize the hypoglycemic effect of insulin glargine. Monitor for changes in fasting and postprandial blood sugars.
  • Insulin Glulisine Somatropin may antagonize the hypoglycemic effect of insulin glulisine. Monitor for changes in fasting and postprandial blood sugars.
  • Liraglutide Somatropin may antagonize the hypoglycemic effect of liraglutide. Monitor for changes in fasting and postprandial blood sugars.
  • Metformin Somatropin may antagonize the hypoglycemic effect of metformin. Monitor for changes in fasting and postprandial blood sugars.
  • Miglitol Somatropin may antagonize the hypoglycemic effect of miglitol. Monitor for changes in fasting and postprandial blood sugars.
  • Nateglinide Somatropin may antagonize the hypoglycemic effect of nateglinide. Monitor for changes in fasting and postprandial blood sugars.
  • Pioglitazone Somatropin may antagonize the hypoglycemic effect of pioglitazone. Monitor for changes in fasting and postprandial blood sugars.
  • Rosiglitazone Somatropin may antagonize the hypoglycemic effect of rosiglitazone. Monitor for changes in fasting and postprandial blood sugars.
  • Saxagliptin Somatropin may antagonize the hypoglycemic effect of saxagliptin. Monitor for changes in fasting and postprandial blood sugars.
  • Sitagliptin Somatropin may antagonize the hypoglycemic effect of sitagliptin. Monitor for changes in fasting and postprandial blood sugars.
  • Tolazamide Somatropin may antagonize the hypoglycemic effect of Tolazamide. Dose adjustments of Tolazamide may be required.
  • Tolbutamide Somatropin may antagonize the hypoglycemic effect of Tolbutamide. Dose adjustments of Tolbutamide may be required.
Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Biotech General
    Sản phẩm biệt dược : BioTropin
  • Công ty : Pfizer
    Sản phẩm biệt dược : Genotropin
  • Công ty : Eli Lilly
    Sản phẩm biệt dược : Humatrope
  • Công ty : Novo Nordisk
    Sản phẩm biệt dược : Norditropin
  • Công ty : Genentech Inc.
    Sản phẩm biệt dược : Nutropin
  • Công ty : Genentech Inc.
    Sản phẩm biệt dược : NutropinAQ
  • Công ty :
    Sản phẩm biệt dược : Omnitrope
  • Công ty : Genentech Inc.
    Sản phẩm biệt dược : Protropin
  • Công ty : Serono SA
    Sản phẩm biệt dược : Saizen
  • Công ty : Serono SA
    Sản phẩm biệt dược : Serostim
  • Công ty : GATE
    Sản phẩm biệt dược : Tev-Tropin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00052
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0169-7704-21
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/AF374232
PharmGKB
http://www.pharmgkb.org/drug/PA451446
Wikipedia
http://en.wikipedia.org/wiki/Somatropin_recombinant
RxList
http://www.rxlist.com/cgi/generic3/nutropin.htm
Drugs.com
http://www.drugs.com/cdi/somatropin-rdna-origin-nonrefrigerated.html
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