Dược Động Học :
▧ Absorption :
Systemic absorption is rapid following aerosol administration.
▧ Metabolism :
Hydrolyzed by esterases in tissue and blood to the active compound colterol. The drug is also conjugatively metabolized to salbutamol 4'-O-sulfate.
▧ Route of Elimination :
Approximately 72% of the inhaled dose is excreted in the urine within 24 hours, 28% as unchanged drug and 44% as metabolite.
▧ Half Life :