Tìm theo
Propericiazine
Các tên gọi khác (10 ) :
  • 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile
  • 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine
  • 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine
  • Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine
  • Periciazina
  • Periciazine
  • Periciazinum
  • Pericyazine
  • Piperocyanomazine
  • Propericiazine
phenothiazines
Thuốc Gốc
Small Molecule
CAS: 2622-26-6
ATC: N05AC01
CTHH: C21H23N3OS
PTK: 365.492
Propericiazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H23N3OS
Phân tử khối
365.492
Monoisotopic mass
365.156183063
InChI
InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
InChI Key
InChIKey=LUALIOATIOESLM-UHFFFAOYSA-N
IUPAC Name
10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
Traditional IUPAC Name
propericiazine
SMILES
OC1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C#N)CC1
Độ tan chảy
116-117 °C
Độ hòa tan
38 mg/L (at 37 °C)
logP
3.52
logS
-3.98
pKa (strongest acidic)
15.18
pKa (Strongest Basic)
8.37
PSA
50.5 Å2
Refractivity
108.4 m3·mol-1
Polarizability
40.87 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Pericyazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects, and an action on the extrapyramidal system.
Cơ Chế Tác Dụng : Propericiazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade of the alpha adrenergic receptors as well as antagonism of the D(1) dopamine receptor.
Độc Tính : In milder cases of phenothiazine overdosage the patient may be agitated, delirious and confused. Frequently he is lethargic or in a comatose state. Twitching, dystonic movements or convulsions may be present and hypotension, cardiovascular collapse, arrhythmias and hypothermia might be observed.
Chỉ Định : For use as adjunctive medication in some psychotic patients. Propericiazine (Pericyazine)is used for the control of residual prevailing hostility, impulsiveness and aggressiveness.
Tương Tác Thuốc :
  • Amphetamine Decreased anorexic effect, may increase pyschotic symptoms
  • Benzphetamine Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
  • Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms.
  • Dextroamphetamine Decreased anorexic effect, may increase pyschotic symptoms
  • Diethylpropion Decreased anorexic effect, may increase psychotic symptoms.
  • Donepezil Possible antagonism of action
  • Fenfluramine Decreased anorexic effect, may increase psychotic symptoms.
  • Galantamine Possible antagonism of action
  • Guanethidine Propericiazine may decrease the effect of guanethidine.
  • Mazindol Decreased anorexic effect, may increase psychotic symptoms.
  • Methamphetamine Decreased anorexic effect, may increase pyschotic symptoms
  • Metrizamide Increased risk of convulsions
  • Phendimetrazine Decreased anorexic effect, may increase pyschotic symptoms
  • Phenmetrazine Decreased anorexic effect, may increase pyschotic symptoms
  • Phentermine Decreased anorexic effect, may increase psychotic symptoms.
  • Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms.
  • Rivastigmine Possible antagonism of action
  • Terfenadine Increased risk of cardiotoxicity and arrhythmias
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Neulactil
  • Công ty :
    Sản phẩm biệt dược : Neuleptil
  • Công ty :
    Sản phẩm biệt dược : Yaz
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01608
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4747
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505085
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01485
ChemSpider
http://www.chemspider.com/Chemical-Structure.4585.html
PharmGKB
http://www.pharmgkb.org/drug/PA164781043
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