Tìm theo
Procaterol
Các tên gọi khác (2) :
  • SID11113915
  • SID26752069
Thuốc Gốc
Small Molecule
CAS: 72332-33-3
ATC: R03CC08, R03AC16
CTHH: C16H22N2O3
PTK: 290.3575
A long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H22N2O3
Phân tử khối
290.3575
Monoisotopic mass
290.16304258
InChI
InChI=1S/C16H22N2O3/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20)/t12-,16+/m0/s1
InChI Key
InChIKey=FKNXQNWAXFXVNW-BLLLJJGKSA-N
IUPAC Name
8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(propan-2-yl)amino]butyl]-1,2-dihydroquinolin-2-one
Traditional IUPAC Name
procaterol
SMILES
CC[C@H](NC(C)C)[C@H](O)C1=C2C=CC(=O)NC2=C(O)C=C1
Độ hòa tan
3.29e-01 g/l
logP
0.88
logS
-3
pKa (strongest acidic)
8.52
pKa (Strongest Basic)
9.88
PSA
81.59 Å2
Refractivity
84.58 m3·mol-1
Polarizability
31.69 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Procaterol is a long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation.
Cơ Chế Tác Dụng : A long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation. [PubChem] Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.
Dược Động Học :
▧ Absorption :
Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses.
Độc Tính : Symptoms of overdose include angina (chest pain), dizziness, dry mouth, fatigue, flu-like symptoms, headache, heart irregularities, high or low blood pressure, high blood sugar, insomnia, muscle cramps, nausea, nervousness, rapid heartbeat, seizures, and tremor.
Chỉ Định : For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Tương Tác Thuốc :
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of procaterol.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of procaterol.
  • Atenolol Antagonism
  • Bisoprolol Antagonism
  • Carvedilol Antagonism
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of procaterol.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of procaterol.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of procaterol.
  • Esmolol Antagonism
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of procaterol.
  • Isocarboxazid Increased arterial pressure
  • Labetalol Antagonism
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Metoprolol Antagonism
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of procaterol.
  • Nadolol Antagonism
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of procaterol.
  • Phenelzine Increased arterial pressure
  • Pindolol Antagonism
  • Propranolol Antagonism
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
  • Timolol Antagonism
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Pro-Air
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01366
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=688561
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507907
ChemSpider
http://www.chemspider.com/Chemical-Structure.599984.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748908
... loading
... loading