Tìm theo
Probucol
Các tên gọi khác (12 ) :
  • 4,4'- (Isopropylidenedithio)bis(2,6-di-tert-butylphenol)
  • Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole
  • Biphenabid
  • Bisbid
  • Bisphenabid
  • DH-581
  • Lesterol
  • Lorelco
  • Lurselle
  • Probucolum
  • Serterol
  • Superlipid
Thực phẩm tăng cường hệ miễn dịch
Thuốc Gốc
Small Molecule
CAS: 23288-49-5
ATC: C10AX02
ĐG : Gallipot , http://www.gallipot.com
CTHH: C31H48O2S2
PTK: 516.842
A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C31H48O2S2
Phân tử khối
516.842
Monoisotopic mass
516.30957216
InChI
InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
InChI Key
InChIKey=FYPMFJGVHOHGLL-UHFFFAOYSA-N
IUPAC Name
2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol
Traditional IUPAC Name
probucol
SMILES
CC(C)(SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C
Độ tan chảy
125 °C
Độ hòa tan
4.18e-05 g/l
logP
10.57
logS
-7.1
pKa (strongest acidic)
10.29
pKa (Strongest Basic)
-5.1
PSA
40.46 Å2
Refractivity
159.26 m3·mol-1
Polarizability
62.35 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
2
Bioavailability
0
Dược Lực Học : Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant drug normally used to prevent vascular disease caused by the free radicals in the body.
Cơ Chế Tác Dụng : A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). Probucol lowers serum cholesterol by increasing the fractional rate of low-density lipoprotein (LDL) catabolism in the final metabolic pathway for cholesterol elimination from the body. Additionally, probucol may inhibit early stages of cholesterol biosynthesis and slightly inhibit dietary cholesterol absorption. Recent information suggests that probucol may inhibit the oxidation and tissue deposition of LDL cholesterol, thereby inhibiting atherogenesis. It appears to inhibits ABCA1-mediated cellular lipid efflux.
Dược Động Học :
▧ Absorption :
Absorption from the gastrointestinal tract is limited and variable (about 7%).
▧ Half Life :
Ranges from 12 hours to more than 500 hours, the longest half-life probably being in adipose tissue.
Chỉ Định : Used to lower LDL and HDL cholesterol.
Tương Tác Thuốc :
  • Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
  • Cyclosporine Probucol decreases the effect of cyclosporine
  • Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
  • Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
  • Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
  • Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
  • Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
  • Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
  • Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
  • Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
  • Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Liều Lượng & Cách Dùng : Tablet - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Probucol powder
    Giá bán buôn : USD >2.45
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Lorelco
  • Công ty :
    Sản phẩm biệt dược : Sinlestal
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01599
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07373
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00476
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50007260
PharmGKB
http://www.pharmgkb.org/drug/PA451107
Wikipedia
http://en.wikipedia.org/wiki/Probucol
Drugs.com
http://www.drugs.com/cons/probucol.html
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