Dược Động Học :
▧ Absorption :
Oral phylloquinone is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phylloquinone is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
▧ Route of Elimination :
Almost no free unmetabolized vitamin K appears in bile or urine.