Tìm theo
Phylloquinone
Các tên gọi khác (19 ) :
  • 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
  • 2-Methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
  • 2-Methyl-3-phytyl-1,4-naphthochinon
  • 2-Methyl-3-phytyl-1,4-naphthoquinone
  • 3-Phytylmenadione
  • alpha-Phylloquinone
  • Fitomenadiona
  • Phyllochinon
  • Phyllochinonum
  • Phylloquinone
  • Phythyl-menadion
  • Phytomenadione
  • Phytomenadionum
  • Phytonadione
  • Phytonadionum
  • Phytylmenadione
  • trans-Phylloquinone
  • Vitamin K1
  • α-phylloquinone
Vitamin
Thuốc Gốc
Small Molecule
CAS: 84-80-0
ATC: B02BA01
ĐG : Amphastar Pharmaceuticals , http://www.amphastar.com
CTHH: C31H46O2
PTK: 450.6957
Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C31H46O2
Phân tử khối
450.6957
Monoisotopic mass
450.349780716
InChI
InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
InChI Key
InChIKey=MBWXNTAXLNYFJB-NKFFZRIASA-N
IUPAC Name
2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione
Traditional IUPAC Name
phytonadione
SMILES
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O
Độ tan chảy
-20 °C
Độ sôi
142.5 °C at 1.00E-03 mm Hg
Độ hòa tan
Insoluble in water
logP
9.3
logS
-6.9
pKa (Strongest Basic)
-7.2
PSA
34.14 Å2
Refractivity
142.96 m3·mol-1
Polarizability
55.92 Å3
Rotatable Bond Count
14
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
2
Bioavailability
0
Dược Lực Học : Phylloquinone is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phylloquinone aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Cơ Chế Tác Dụng : Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation. Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phylloquinone results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria.
Dược Động Học :
▧ Absorption :
Oral phylloquinone is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phylloquinone is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
▧ Route of Elimination :
Almost no free unmetabolized vitamin K appears in bile or urine.
Độc Tính : The intravenous LD50 of phylloquinone in the mouse is 41.5 and 52 mL/kg for the 0.2% and 1% concentrations, respectively.
Chỉ Định : For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia.
Tương Tác Thuốc :
  • Warfarin Phytonadione (vitamin K) may antagonize the anticoagulant effects of warfarin. Monitor for changes in prothrombin time if phytonadione intake (either via supplements or vitamin K-rich foods) is increased or decreased.
Liều Lượng & Cách Dùng : Injection, solution - Intramuscular
Injection, solution - Intravenous
Injection, solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Vitamin K1 10 mg/ml
    Giá bán buôn : USD >2.76
    Đơn vị tính : ml
  • Biệt dược thương mại : Vitamin K1 Pediatric 2 mg/ml
    Giá bán buôn : USD >4.79
    Đơn vị tính : ml
  • Biệt dược thương mại : Mephyton 5 mg tablet
    Giá bán buôn : USD >5.95
    Đơn vị tính : tablet
  • Biệt dược thương mại : Vitamin k1 liquid
    Giá bán buôn : USD >35.0
    Đơn vị tính : g
  • Biệt dược thương mại : Phytonadione liquid
    Giá bán buôn : USD >66.0
    Đơn vị tính : g
  • Biệt dược thương mại : Phytonadione crystal
    Giá bán buôn : USD >111.13
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Aqua-Mephyton
  • Công ty :
    Sản phẩm biệt dược : Konakion
  • Công ty :
    Sản phẩm biệt dược : Mephyton
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01022
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C02059
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00148
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0548-1240-00
PharmGKB
http://www.pharmgkb.org/drug/PA450961
Wikipedia
http://en.wikipedia.org/wiki/Phytonadione
RxList
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Drugs.com
http://www.drugs.com/cdi/phytonadione.html
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