Tìm theo
Perflutren
Các tên gọi khác (9 ) :
  • 1,1,1,2,2,3,3,3-Octafluoropropane
  • Definity
  • FC 218
  • Freon 218
  • Octafluoropropane
  • Octafluorpropan
  • Oktafluorpropan
  • Perfluoropropane
  • Perflutren
contrast media
Thuốc Gốc
Small Molecule
CAS: 76-19-7
ĐG : Bristol-Myers Squibb Co. , http://www.bms.com
CTHH: C3F8
PTK: 188.0193
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C3F8
Phân tử khối
188.0193
Monoisotopic mass
187.98722564
InChI
InChI=1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI Key
InChIKey=QYSGYZVSCZSLHT-UHFFFAOYSA-N
IUPAC Name
octafluoropropane
Traditional IUPAC Name
definity
SMILES
FC(F)(F)C(F)(F)C(F)(F)F
Độ tan chảy
-147.6 °C
Độ sôi
-36.6 °C
Độ hòa tan
5.7 mg/L (at 15 °C)
logP
3
logS
-3.1
Refractivity
17.54 m3·mol-1
Polarizability
7.1 Å3
Polar Surface Area (PSA)
0
Rotatable Bond Count
2
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. It provide contrast enhancement of the endocardial borders during echocardiography. The perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood.
Cơ Chế Tác Dụng : Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients. Perflutren is comprised of gas-filled microspheres that are injected or infused into the body. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
Dược Động Học :

▧ Metabolism :
OFP is not metabolized. The phospholipid components of the microspheres are thought to be metabolized to free fatty acids.
▧ Half Life :
The mean half-life of OFP in blood 1.9 minutes
Độc Tính : There is new temporal evidence that perflutren may be associated with new-onset seizure activity following perflutren microbubble contrast injection during dobutamine-atropine stress echocardiography. [PMID: 23432576]
Chỉ Định : Used as an ultrasound contrast imaging in cardiology and radiology.
Tương Tác Thuốc :
  • Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
  • Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
  • Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
  • Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
  • Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
  • Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
  • Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
  • Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
  • Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
  • Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Liều Lượng & Cách Dùng : Suspension - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Optison vial
    Giá bán buôn : USD >56.16
    Đơn vị tính : ml
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00556
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01738
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/11994-011-04
PharmGKB
http://www.pharmgkb.org/drug/PA164781354
Wikipedia
http://en.wikipedia.org/wiki/Octafluoropropane
RxList
http://www.rxlist.com/cgi/generic3/definity.htm
Drugs.com
http://www.drugs.com/cdi/perflutren-lipid-microspheres.html
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