Tìm theo
Oxyphenbutazone
Các tên gọi khác (3) :
  • Oxifenbutazona
  • Oxiphenbutazone
  • Oxyphenbutazonum
anti inflammatory agents non steroidal
Thuốc Gốc
Small Molecule
CAS: 129-20-4
ATC: M02AA04, S01BC02, M01AA03
CTHH: C19H20N2O3
PTK: 324.3737
Oxyphenbutazone was withdrawn from the Canadian market in March 1985 due to concerns regarding bone marrow suppression.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H20N2O3
Phân tử khối
324.3737
Monoisotopic mass
324.147392516
InChI
InChI=1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3
InChI Key
InChIKey=HFHZKZSRXITVMK-UHFFFAOYSA-N
IUPAC Name
4-butyl-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione
Traditional IUPAC Name
oxyphenbutazone
SMILES
CCCCC1C(=O)N(N(C1=O)C1=CC=C(O)C=C1)C1=CC=CC=C1
Độ tan chảy
96 °C
Độ hòa tan
60 mg/L (at 30 °C)
logP
2.72
logS
-3.73
pKa (strongest acidic)
4.87
pKa (Strongest Basic)
-6
PSA
60.85 Å2
Refractivity
90.74 m3·mol-1
Polarizability
35.14 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Tương Tác Thuốc :
  • Acenocoumarol The NSAID, oxyphenbutazone, may increase the anticoagulant effect of acenocoumarol.
  • Alendronate Increased risk of gastric toxicity
  • Anisindione The NSAID, oxyphenbutazone, may increase the anticoagulant effect of anisindione.
  • Dicoumarol The NSAID, oxyphenbutazone, may increase the anticoagulant effect of dicumarol.
  • Ethotoin The NSAID, oxyphenbutazone, may increase the hydantoin effect of ethotoin.
  • Fosphenytoin The NSAID, oxphenbutazone, may increase the hydantoin effect of fosphenytoin.
  • Mephenytoin The NSAID, oxyphenbutazone, may increase the hydantoin effect of mephenytoin.
  • Phenytoin The NSAID, oxphenbutazone, may increase the therapeutic and adverse effects of phenytoin.
  • Warfarin The NSAID, oxyphenbutazone, may increase the anticoagulant effect of warfarin.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Oxyphenbutazone
  • Công ty :
    Sản phẩm biệt dược : Reozon
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB03585
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4641
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507285
ChemSpider
http://www.chemspider.com/Chemical-Structure.4480.html
PharmGKB
http://www.pharmgkb.org/drug/PA450750
Wikipedia
http://en.wikipedia.org/wiki/Oxyphenbutazone
... loading
... loading