Tìm theo
Nitrazepam
Các tên gọi khác (38 ) :
  • 1,3-dihydro-7-Nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 2,3-dihydro-7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2-one
  • 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
  • Apodorm
  • Atempol
  • Benzalin
  • Calsmin
  • Eatan
  • Eunoctin
  • Gerson
  • Hipnax
  • Hipsal
  • Ibrovek
  • Imeson
  • Imesont
  • Mogadon
  • N-Desmethylnimetazepam
  • Nelbon
  • Nelmat
  • Neozepam
  • Neuchlonic
  • Nitrados
  • Nitrazepamum
  • Paxisyn
  • Pelson
  • Persopit
  • Radedorm
  • Relact
  • Remnos
  • Ro 4-5360
  • Ro 5-3059
  • Somitran
  • Sonebon
  • Sonnolin
  • Surem
  • Trazenin
  • Unisomnia
Thuốc chống lo âu, hoảng sợ
Thuốc Gốc
Small Molecule
CAS: 146-22-5
ATC: N05CD02
CTHH: C15H11N3O3
PTK: 281.2661
A benzodiazepine derivative used as an anticonvulsant and hypnotic.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H11N3O3
Phân tử khối
281.2661
Monoisotopic mass
281.080041233
InChI
InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)
InChI Key
InChIKey=KJONHKAYOJNZEC-UHFFFAOYSA-N
IUPAC Name
7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Traditional IUPAC Name
nitrazepam
SMILES
[O-][N+](=O)C1=CC2=C(NC(=O)CN=C2C2=CC=CC=C2)C=C1
Độ tan chảy
225 °C
Độ hòa tan
2.99e-02 g/l
logP
2.25
logS
-3.8
pKa (strongest acidic)
11.9
pKa (Strongest Basic)
2.61
PSA
87.28 Å2
Refractivity
79.22 m3·mol-1
Polarizability
27.59 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Nitrazepam is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative, anxiolytic, amnestic, anticonvulsant, and skeletal muscle relaxant properties. Nitrazepam shortens the time required to fall asleep and lengthens the duration of sleep. It is also useful for the management of myoclonic seizures.
Cơ Chế Tác Dụng : A benzodiazepine derivative used as an anticonvulsant and hypnotic. Nitrazepam belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causing an enhanced binding of GABA (gamma amino butyric acid) to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, involved in inducing sleepiness, muscular relaxation and control of anxiety and fits, and slows down the central nervous system. The anticonvulsant properties of nitrazepam and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.
Dược Động Học :
▧ Absorption :
Bioavailability is 53-94% following oral administration.
▧ Half Life :
15-38 hours (mean elimination half life 26 hours).
Độc Tính : Nitrazepam is a drug which is very frequently involved in drug intoxication, including overdose. Nitrazepam overdose may result in stereotypical symptoms of benzodiazepine overdose including intoxication, impaired balance, slurred speech. In cases of severe overdose this may progress to a comatose state with the possibility of death.
Chỉ Định : Used to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Alodorm
  • Công ty :
    Sản phẩm biệt dược : Arem
  • Công ty :
    Sản phẩm biệt dược : Benzalin
  • Công ty :
    Sản phẩm biệt dược : Insoma
  • Công ty :
    Sản phẩm biệt dược : Mogadon
  • Công ty :
    Sản phẩm biệt dược : Nitrados
  • Công ty :
    Sản phẩm biệt dược : Nitrazadon
  • Công ty :
    Sản phẩm biệt dược : Nitrosun
  • Công ty :
    Sản phẩm biệt dược : Ormodon
  • Công ty :
    Sản phẩm biệt dược : Pacisyn
  • Công ty :
    Sản phẩm biệt dược : Paxadorm
  • Công ty :
    Sản phẩm biệt dược : Remnos
  • Công ty :
    Sản phẩm biệt dược : Somnite
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01595
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4506
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505806
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07487
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00531
ChemSpider
http://www.chemspider.com/Chemical-Structure.4350.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020856
PharmGKB
http://www.pharmgkb.org/drug/PA10242
Wikipedia
http://en.wikipedia.org/wiki/Nitrazepam
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