Tìm theo
Nandrolone phenpropionate
Các tên gọi khác (12 ) :
  • 19NTPP
  • Durabolin
  • Nadrolone phenylpropionate
  • Nandrolon phenylpropionate
  • Nandrolone phenpropionate
  • Nandrolone phenylpionate
  • Nandrolone phenylpropionate
  • Norandrolone phenyl propionate
  • Norandrostenolone phenylpropionate
  • Nortestosterone phenylpropionate
  • NPP
  • NTPP
anabolic agents
Thuốc Gốc
Small Molecule
CAS: 434-22-0
ATC: A14AB01, S01XA11
ĐG : C.O. Truxton Inc.
CTHH: C27H34O3
PTK: 406.5571
C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of estradiol to resemble testosterone but less one carbon at the 19 position. It is a schedule III drug in the U.S.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C27H34O3
Phân tử khối
406.5571
Monoisotopic mass
406.250794954
InChI
InChI=1S/C27H34O3/c1-27-16-15-22-21-11-9-20(28)17-19(21)8-10-23(22)24(27)12-13-25(27)30-26(29)14-7-18-5-3-2-4-6-18/h2-6,17,21-25H,7-16H2,1H3/t21-,22+,23+,24-,25-,27-/m0/s1
InChI Key
InChIKey=UBWXUGDQUBIEIZ-QNTYDACNSA-N
IUPAC Name
(1S,2R,10R,11S,14S,15S)-15-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl 3-phenylpropanoate
Traditional IUPAC Name
nandrolone
SMILES
[H][C@@]12CC[C@H](OC(=O)CCC3=CC=CC=C3)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]
Độ tan chảy
118 °C
Độ hòa tan
3090 mg/L (at 25 °C)
logP
2.62
logS
-6
pKa (strongest acidic)
19.28
pKa (Strongest Basic)
-4.7
PSA
43.37 Å2
Refractivity
118.43 m3·mol-1
Polarizability
47.83 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
5
Bioavailability
1
Dược Lực Học : Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth.
Cơ Chế Tác Dụng : C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of estradiol to resemble testosterone but less one carbon at the 19 position. It is a schedule III drug in the U.S. Nandrolone is an androgen receptor agonist. The drug bound to the receptor complexes which allows it to enter the nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
Dược Động Học :
▧ Absorption :
The absorption after oral dosing is rapid for testosterone and probably for other anabolic steroids, but there is extensive first-pass hepatic metabolism for all anabolic steroids except those that are substituted at the 17-alpha position. The rate of absorption from subcutaneous or intramuscular depots depends on the product and its formulation. Absorption is slow for the lipid-soluble esters such as the cypionate or enanthate, and for oily suspensions.
▧ Protein binding :
58%
▧ Metabolism :
Nandrolone is unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product known as Dihydronandrolone.
▧ Half Life :
The elimination half-life from plasma is very short.
Chỉ Định : For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema.
Tương Tác Thuốc :
  • Warfarin Nandrolone may increase the serum concentration and anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if nandrolone is initiated, discontinued or dose changed.
Liều Lượng & Cách Dùng : Liquid - Intramuscular
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Durabolin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00984
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=229455
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506276
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08155
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00956
ChemSpider
http://www.chemspider.com/Chemical-Structure.199761.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746281
Wikipedia
http://en.wikipedia.org/wiki/Nandrolone
Drugs.com
http://www.drugs.com/cdi/nandrolone.html
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