Tìm theo
Nandrolone decanoate
Các tên gọi khác (3) :
  • 19-nortestosterone decanoate
  • Deca-durabolin
  • Nandrolone 17β-decanoate
anabolic agents
Thuốc Gốc
Small Molecule
CAS: 360-70-3
CTHH: C28H44O3
PTK: 428.6472
C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of estradiol to resemble testosterone but less one carbon at the 19 position. It is a schedule III drug in the U.S.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C28H44O3
Phân tử khối
428.6472
Monoisotopic mass
428.329045274
InChI
InChI=1S/C28H44O3/c1-3-4-5-6-7-8-9-10-27(30)31-26-16-15-25-24-13-11-20-19-21(29)12-14-22(20)23(24)17-18-28(25,26)2/h19,22-26H,3-18H2,1-2H3/t22-,23+,24+,25-,26-,28-/m0/s1
InChI Key
InChIKey=JKWKMORAXJQQSR-MOPIKTETSA-N
IUPAC Name
(1S,2R,10R,11S,14S,15S)-15-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl decanoate
Traditional IUPAC Name
(1S,2R,10R,11S,14S,15S)-15-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl decanoate
SMILES
CCCCCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C
Độ tan chảy
118 °C
Độ hòa tan
3.09 mg/mL at 25 °C
logP
2.62
logS
-6.4
pKa (strongest acidic)
19.28
pKa (Strongest Basic)
-4.7
PSA
43.37 Å2
Refractivity
125.94 m3·mol-1
Polarizability
53.65 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth.
Cơ Chế Tác Dụng : C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of estradiol to resemble testosterone but less one carbon at the 19 position. It is a schedule III drug in the U.S. Nandrolone is an androgen receptor agonist. The drug bound to the receptor complexes which allows it to enter the nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
Dược Động Học :

▧ Protein binding :
58%
▧ Metabolism :
Nandrolone is unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product known as Dihydronandrolone.
Chỉ Định : For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema.
Tương Tác Thuốc :
  • Warfarin Nandrolone may increase the serum concentration and anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if nandrolone is initiated, discontinued or dose changed.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Deca-Durabol
  • Công ty :
    Sản phẩm biệt dược : Deca-Durabolin
  • Công ty :
    Sản phẩm biệt dược : Retabolil
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08804
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08154
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00955
ChemSpider
http://www.chemspider.com/Chemical-Structure.9296.html
PharmGKB
http://www.pharmgkb.org/drug/PA165958423
Wikipedia
http://en.wikipedia.org/wiki/Nandrolone_decanoate
Drugs.com
http://www.drugs.com/cdi/nandrolone.html
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