Tìm theo
Methoxamine
Các tên gọi khác (9 ) :
  • Méthoxamédrine
  • Methoxamin
  • Méthoxamine
  • Methoxaminum
  • Metossamina
  • Metoxamina
  • Pseudomethoxamine
  • SID90341132
  • Vasoxyl
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 390-28-3
ATC: C01CA10
CTHH: C11H17NO3
PTK: 211.2576
An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H17NO3
Phân tử khối
211.2576
Monoisotopic mass
211.120843415
InChI
InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
InChI Key
InChIKey=WJAJPNHVVFWKKL-UHFFFAOYSA-N
IUPAC Name
2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
Traditional IUPAC Name
methoxamine
SMILES
COC1=CC(C(O)C(C)N)=C(OC)C=C1
Độ hòa tan
Soluble (185 g/L)
logP
0.8
logS
-1.4
pKa (strongest acidic)
13.61
pKa (Strongest Basic)
9.28
PSA
64.71 Å2
Refractivity
57.84 m3·mol-1
Polarizability
22.79 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Methoxamine is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Methoxamine acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.
Cơ Chế Tác Dụng : An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. [PubChem] Methoxamine acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic and diastolic).
Dược Động Học :

▧ Protein binding :
Low
Chỉ Định : Indicated for the treatment and management of hypotension.
Tương Tác Thuốc :
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of methoxamine.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of methoxamine.
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of methoxamine.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of methoxamine.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of methoxamine.
  • Guanethidine Methoxamine may decrease the effect of guanethidine.
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of methoxamine.
  • Isocarboxazid Increased arterial pressure
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of methoxamine.
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of methoxamine.
  • Phenelzine Increased arterial pressure
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
  • Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the vasopressor effect of the alpha1-agonist, Methoxamine. Concomitant therapy should be avoided.
  • Trimipramine Trimipramine may increase the vasopressor effect of the alpha1-agonist, Methoxamine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Nippon Shinyaku
    Sản phẩm biệt dược : Mexan
  • Công ty :
    Sản phẩm biệt dược : Vasoxine
  • Công ty :
    Sản phẩm biệt dược : Vasoxyl
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00723
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6082
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506264
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07513
ChemSpider
http://www.chemspider.com/Chemical-Structure.5857.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026777
PharmGKB
http://www.pharmgkb.org/drug/PA450431
Wikipedia
http://en.wikipedia.org/wiki/Methoxamine
... loading
... loading