Tìm theo
Metaraminol
Các tên gọi khác (15 ) :
  • (-)-Erythro-metaraminol
  • 1-(m-Hydroxyphenyl)-2-amino-1-propanol
  • 1-Metaraminol
  • 2-Amino-1-(m-hydroxyphenyl)-1-propanol
  • 3-Hydroxyphenylisopropanolamine
  • alpha-(1-Aminoethyl)-3-hydroxybenzenemethanol
  • alpha-(m-Hydroxyphenyl)-beta-aminopropanol
  • Hydroxynorephedrine
  • L-Metaraminol
  • m-Hydroxy norephedrine
  • m-Hydroxyphenylpropanolamine
  • m-Hydroxypropadrine
  • Metaraminol
  • Métaraminol
  • Metaraminolum
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 54-49-9
ATC: C01CA09
ĐG : Physicians Total Care Inc. , http://www.physicianstotalcare.com
CTHH: C9H13NO2
PTK: 167.205
An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H13NO2
Phân tử khối
167.205
Monoisotopic mass
167.094628665
InChI
InChI=1S/C9H13NO2/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6,9,11-12H,10H2,1H3/t6-,9-/m0/s1
InChI Key
InChIKey=WXFIGDLSSYIKKV-RCOVLWMOSA-N
IUPAC Name
3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol
Traditional IUPAC Name
metaraminol
SMILES
C[C@H](N)[C@H](O)C1=CC(O)=CC=C1
Độ tan chảy
107.5 °C
Độ sôi
218 °C
Độ hòa tan
1000 g/L
logP
-0.27
logS
-1.1
pKa (strongest acidic)
9.03
pKa (Strongest Basic)
9.68
PSA
66.48 Å2
Refractivity
46.89 m3·mol-1
Polarizability
17.84 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
8.79
Dược Lực Học : Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.
Cơ Chế Tác Dụng : An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension. [PubChem] Metaraminol acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic). Its effect is thought to be associated with the inhibition of adenyl cyclase which leads to an inhibition of the production of cAMP. Another effect of Metaraminol is that it releases norepinephrine from its storage sites indirectly.
Dược Động Học :
▧ Absorption :
The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.
▧ Protein binding :
Approximately 45%
▧ Metabolism :
Hepatic
Độc Tính : LD50=240 mg/kg (rat, oral); LD50=99 mg/kg (mouse, oral)
Chỉ Định : For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
Tương Tác Thuốc :
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of metaraminol.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of metaraminol.
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of metaraminol.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of metaraminol.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of metaraminol.
  • Guanethidine Metaraminol may decrease the effect of guanethidine.
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of metaraminol.
  • Isocarboxazid Increased arterial pressure
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of metaraminol.
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of metaraminol.
  • Phenelzine Increased arterial pressure
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
Liều Lượng & Cách Dùng : Injection, solution - Intramuscular
Injection, solution - Intravenous drip
Injection, solution - Subcutaneous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Merck
    Sản phẩm biệt dược : Aramine
  • Công ty :
    Sản phẩm biệt dược : Metaramin
  • Công ty :
    Sản phẩm biệt dược : Pressonex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00610
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5906
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505593
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07146
ChemSpider
http://www.chemspider.com/Chemical-Structure.5695.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748761
Wikipedia
http://en.wikipedia.org/wiki/Metaraminol
RxList
http://www.rxlist.com/cgi/generic2/metar.htm
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