Tìm theo
Mephentermine
Các tên gọi khác (2) :
  • Mephentermine
  • SID11112475
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 100-92-5
ATC: C01CA11
CTHH: C11H17N
PTK: 163.2594
A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H17N
Phân tử khối
163.2594
Monoisotopic mass
163.136099549
InChI
InChI=1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3
InChI Key
InChIKey=RXQCGGRTAILOIN-UHFFFAOYSA-N
IUPAC Name
methyl(2-methyl-1-phenylpropan-2-yl)amine
Traditional IUPAC Name
mephentermine
SMILES
CNC(C)(C)CC1=CC=CC=C1
Độ tan chảy
< 25 °C
Độ hòa tan
4.57e-01 g/l
logP
2.52
logS
-2.5
pKa (Strongest Basic)
10.3
PSA
12.03 Å2
Refractivity
53.12 m3·mol-1
Polarizability
19.79 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Mephentermine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)
Cơ Chế Tác Dụng : A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248) Mephentermine is an alpha adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.
Dược Động Học :

▧ Metabolism :
Hepatic, by N-demethylation and then p-hydroxylation.
▧ Half Life :
17 to 18 hours.
Chỉ Định : Used to maintain blood pressure in hypotensive states.
Tương Tác Thuốc :
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of mephentermine.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of mephentermine.
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of mephentermine.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of mephentermine.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of mephentermine.
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of mephentermine.
  • Isocarboxazid Increased arterial pressure
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of mephentermine.
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of mephentermine.
  • Phenelzine Increased arterial pressure
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
  • Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the vasopressor effect of the alpha1-agonist, Mephentermine. Concomitant therapy should be avoided.
  • Trimipramine Trimipramine may increase the vasopressor effect of the alpha1-agonist, Mephentermine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Wyamine
  • Công ty :
    Sản phẩm biệt dược : Wyfentermina
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01365
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3677
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505918
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07889
ChemSpider
http://www.chemspider.com/Chemical-Structure.3549.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745533
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