Tìm theo
Magnesium salicylate
Các tên gọi khác (1) :
  • Magnesium salicylate anhydrous
Thuốc Gốc
Small Molecule
ĐG : Caraco Pharmaceutical Labs , http://www.caraco.com
CTHH: C14H10MgO6
PTK: 298.531
Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain. It is also used to treat headaches, general back pain, and certain joint pains like arthritis. It is found in a variety of over-the-counter (OTC) medications as an anti-inflammatory, primarily for back-pain relief. Magnesium Salicylate can be an effective OTC alternative to prescription NSAIDs, with both anti-inflamatory and pain-relieving effects. Though the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H10MgO6
Phân tử khối
298.531
Monoisotopic mass
298.03277995
InChI
InChI=1S/2C7H6O3.Mg/c2*8-6-4-2-1-3-5(6)7(9)10;/h2*1-4,8H,(H,9,10);/q;;+2/p-2
InChI Key
InChIKey=MQHWFIOJQSCFNM-UHFFFAOYSA-L
IUPAC Name
magnesium(2+) ion bis(2-hydroxybenzoate)
Traditional IUPAC Name
magnesium disalicylate
SMILES
[Mg++].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O
Độ hòa tan
6.86e-02 g/l
logP
1.98
logS
-3.6
pKa (strongest acidic)
2.79
pKa (Strongest Basic)
-6.3
PSA
60.36 Å2
Refractivity
46.13 m3·mol-1
Polarizability
12.38 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain. It is also used to treat headaches, general back pain, and certain joint pains like arthritis. It is found in a variety of over-the-counter (OTC) medications as an anti-inflammatory, primarily for back-pain relief. Magnesium Salicylate can be an effective OTC alternative to prescription NSAIDs, with both anti-inflamatory and pain-relieving effects. Though the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results. Most NSAIDs act as nonselective inhibitors of the enzyme cyclooxygenase (COX), inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation.
Chỉ Định : Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain
Tương Tác Thuốc :
  • Betamethasone The corticosteroid, betamethasone, may decrease the effect of magnesium salicylate.
  • Dexamethasone The corticosteroid, dexamethasone, may decrease the effect of magnesium salicylate.
  • Fludrocortisone The corticosteroid, fludrocortisone, may decrease the effect of magnesium salicylate.
  • Gatifloxacin Formation of non-absorbable complexes
  • Gemifloxacin Formation of non-absorbable complexes
  • Gliclazide The salicylate, magnesium salicylate, increases the effect of the sulfonylurea, gliclazide.
  • Glyburide The salicylate, magnesium salicylate, increases the effect of the sulfonylurea, glibenclamide.
  • Hydrocortisone The corticosteroid, hydrocortisone, may decrease the effect of magnesium salicylate.
  • Methazolamide The salicylate, magnesium salicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
  • Methotrexate The salicylate, magnesium salicylate, increases the effect and toxicity of methotrexate.
  • Minocycline Formation of non-absorbable complexes
  • Prednisolone The corticosteroid, prednisolone, may decrease the effect of magnesium salicylate.
  • Prednisone The corticosteroid, prednisolone, may decrease the effect of magnesium salicylate.
  • Probenecid The salicylate, magnesium salicylate, decreases the uricosuric effect of probenecid.
  • Quinidine The antacid increases the effect of quinidine
  • Tetracycline Formation of non-absorbable complexes
  • Triamcinolone The corticosteroid, triamcinolone, may decrease the effect of magnesium salicylate.
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Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01397
PharmGKB
http://www.pharmgkb.org/drug/PA450300
Wikipedia
http://en.wikipedia.org/wiki/Magnesium_salicylate
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