Tìm theo
Liothyronine
Các tên gọi khác (15 ) :
  • 3,3',5-triiodo-L-thyronine
  • 3,5,3'-Triiodo-L-thyronine
  • 3,5,3'-Triiodothyronine
  • 3,5,3'TRIIODOTHYRONINE
  • 4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine
  • L-3,5,3'-Triiodothyronine
  • L-T3
  • Liothyronine
  • Liothyroninum
  • Liotironina
  • O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
  • T3
  • Tertroxin
  • Tresitope
  • Triiodothyronine
Hormon thượng thận và những chất tổng hợp thay thế
Thuốc Gốc
Small Molecule
CAS: 6893-02-3
ATC: H03AA02
ĐG : Amerisource Health Services Corp. , http://www.amerisourcebergen.com
CTHH: C15H12I3NO4
PTK: 650.9735
The L-triiodothyronine (T3, liothyronine) thyroid hormone is normally synthesized and secreted by the thyroid gland in much smaller quantities than L-tetraiodothyronine (T4, levothyroxine, L-thyroxine). Most T3 is derived from peripheral monodeiodination of T4 at the 5 position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H12I3NO4
Phân tử khối
650.9735
Monoisotopic mass
650.790038137
InChI
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChI Key
InChIKey=AUYYCJSJGJYCDS-LBPRGKRZSA-N
IUPAC Name
(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
Traditional IUPAC Name
liothyronine
SMILES
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O
Độ tan chảy
236-237
Độ hòa tan
3.96 mg/L (at 37 °C)
logP
2.9
logS
-5.22
pKa (strongest acidic)
0.3
pKa (Strongest Basic)
9.48
PSA
92.78 Å2
Refractivity
113.43 m3·mol-1
Polarizability
43.92 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Dược Lực Học : Thyroid hormone drugs are natural or synthetic preparations containing T4 or T3 or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. Liothyronine (T3) contains three atoms of iodine and is formed by the coupling of one molecule of diiodotyrosine (DIT) with one molecule of monoiodotyrosine (MIT). These hormones enhance oxygen consumption by most tissues of the body and increase the basal metabolic rate and the metabolism of carbohydrates, lipids and proteins. Thus, they exert a profound influence on every organ system in the body and are of particular importance in the development of the central nervous system.
Cơ Chế Tác Dụng : The L-triiodothyronine (T3, liothyronine) thyroid hormone is normally synthesized and secreted by the thyroid gland in much smaller quantities than L-tetraiodothyronine (T4, levothyroxine, L-thyroxine). Most T3 is derived from peripheral monodeiodination of T4 at the 5 position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. [PubChem] The hormones, T4 and T3, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major form of thyroid hormone in the blood is thyroxine (T4). This is converted to the more active liothyronine form by deiodinases in peripheral tissues. Liothyronine acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline). The thyroid hormones are essential to proper development and differentiation of all cells of the human body. To various extents T4 and T3 regulate protein, fat and carbohydrate metabolism. Their most pronounced effect is on how human cells use energetic compounds. The thyroid hormone derivatives bind to the thyroid hormone receptors initially to initiate their downstream effects.
Dược Động Học :
▧ Absorption :
95% in 4 hours
▧ Protein binding :
99.7%
▧ Half Life :
2.5 days
Chỉ Định : Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis.
Tương Tác Thuốc :
  • Calcium Acetate Calcium salts such as calcium acetate may diminish the therapeutic effect of thyroid products such as liothyronine. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
  • Calcium Chloride Calcium salts such as calcium chloride may diminish the therapeutic effect of thyroid products such as liothyronine. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
  • Cholestyramine The resin, cholestyramine, decreases the absorption of the thyroid hormones, liothyronine.
  • Colestipol The resin, colestipol, decreases the absorption of the thyroid hormone, liothyronine.
  • Digoxin The thyroid hormone, liothyronine, decreases the effect of digoxin.
  • Warfarin Liothyronine may contribute to the anticoagulant effect of warfarin by increasing the metabolism of vitamin K-dependent clotting factors. Monitor for changes in prothrombin time and anticoagulant effects if liothyronine is initiated, discontinued or dose changed.
Liều Lượng & Cách Dùng : Injection - Intravenous - 10 mcg/ml
Tablet - Oral - 25 mcg
Tablet - Oral - 5 mcg
Tablet - Oral - 50 mcg
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Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00279
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5920
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506352
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C02465
ChemSpider
http://www.chemspider.com/Chemical-Structure.5707.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18860
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/39822-0151-1
PharmGKB
http://www.pharmgkb.org/drug/PA164778866
Wikipedia
http://en.wikipedia.org/wiki/Liothyronine
RxList
http://www.rxlist.com/cgi/generic3/liothyronine.htm
Drugs.com
http://www.drugs.com/cdi/liothyronine.html
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