Tìm theo
Isotretinoin
Các tên gọi khác (13 ) :
  • (7e,9e,11e,13Z)-Retinoic acid
  • 13-cis-Retinoic acid
  • 13-cis-Vitamin a acid
  • 13-RA
  • Accutane
  • Amnesteem
  • cis-RA
  • Claravis
  • Isotretinoina
  • Isotretinoine
  • Isotretinoino
  • Isotretinoinum
  • Neovitamin a acid
Thuốc điều trị bệnh da liễu
Thuốc Gốc
Small Molecule
CAS: 4759-48-2
ĐG : Barr Pharmaceuticals
CTHH: C20H28O2
PTK: 300.4351
Isotretinoin is a medication used for the treatment of severe acne. It is sometimes used in prevention of certain skin cancers. It is a retinoid, meaning it derives from vitamin A and is found in small quantities naturally in the body. Isotretinoin binds to and activates nuclear retinoic acid receptors (RAR), thereby regulating cell proliferation and differentiation. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H28O2
Phân tử khối
300.4351
Monoisotopic mass
300.20893014
InChI
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
InChI Key
InChIKey=SHGAZHPCJJPHSC-XFYACQKRSA-N
IUPAC Name
(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
Traditional IUPAC Name
accutane
SMILES
C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C\C(O)=O
Độ hòa tan
4.77e-03 g/l
logP
4.2
logS
-4.8
pKa (strongest acidic)
5
PSA
37.3 Å2
Refractivity
97.79 m3·mol-1
Polarizability
36.15 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Ghose Filter
true
Dược Lực Học : Isotretinoin, a retinoid, is indicated in the treatment of severe recalcitrant nodular acne. Nodules are inflammatory lesions with a diameter of 5 mm or greater. The nodules may become suppurative or hemorrhagic. "Severe," by definition, means "many" as opposed to "few or several" nodules. Clinical improvement in nodular acne patients occurs in association with a reduction in sebum secretion. The decrease in sebum secretion is temporary and is related to the dose and duration of treatment with Accutane, and reflects a reduction in sebaceous gland size and an inhibition of sebaceous gland differentiation.
Cơ Chế Tác Dụng : Isotretinoin is a medication used for the treatment of severe acne. It is sometimes used in prevention of certain skin cancers. It is a retinoid, meaning it derives from vitamin A and is found in small quantities naturally in the body. Isotretinoin binds to and activates nuclear retinoic acid receptors (RAR), thereby regulating cell proliferation and differentiation. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. Isotretinoin noticeably reduces the production of sebum and shrinks the sebaceous glands. It stabilises keratinization and prevents comedones from forming. It also reduces inflammation in moderate-severe inflammatory acne. The exact mechanism of action is unknown, however it is known that it alters DNA transcription.
Dược Động Học :

▧ Protein binding :
99.9%
▧ Route of Elimination :
Isotretinoin and its metabolites are further metabolized into conjugates, which are then excreted in urine and feces. The metabolites of isotretinoin and any conjugates are ultimately excreted in the feces and urine in relatively equal amounts (total of 65% to 83%).
▧ Half Life :
17-50 hours
▧ Clearance :
* 96 +/- 6.27 L/hr [severe recalcitrant nodular acne pediatric Patients, 12 to 15 Years]
Độc Tính : Isotretinoin is teratogenic. It also causes mucocutaneous side effects suck as cheilitis, dry skin, and dry eyes.
Chỉ Định : For the treatment of severe recalcitrant nodular acne
Tương Tác Thuốc :
  • Carbamazepine Isotretinoine decreases the effect of carbamazepine
  • Demeclocycline Increased risk of intracranial hypertension
  • Doxycycline Increased risk of intracranial hypertension
  • Methacycline Increased risk of intracranial hypertension
  • Minocycline Increased risk of intracranial hypertension
  • Oxytetracycline Increased risk of intracranial hypertension
  • Rolitetracycline Increased risk of intracranial hypertension
  • Tetracycline Increased risk of intracranial hypertension
  • Vitamin A Isotretinoin increases the risk of vitamin A toxicity. Avoid vitamin A supplementation while taking isotretinoin.
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Clarus 10 mg Capsule
    Giá bán buôn : USD >1.05
    Đơn vị tính : capsule
  • Biệt dược thương mại : Clarus 40 mg Capsule
    Giá bán buôn : USD >2.14
    Đơn vị tính : capsule
  • Biệt dược thương mại : Sotret 10 mg capsule
    Giá bán buôn : USD >7.31
    Đơn vị tính : capsule
  • Biệt dược thương mại : Sotret 30 mg capsule
    Giá bán buôn : USD >8.44
    Đơn vị tính : capsule
  • Biệt dược thương mại : Sotret 20 mg capsule
    Giá bán buôn : USD >8.67
    Đơn vị tính : capsule
  • Biệt dược thương mại : Sotret 40 mg capsule
    Giá bán buôn : USD >10.08
    Đơn vị tính : capsule
  • Biệt dược thương mại : Accutane 10 mg capsule
    Giá bán buôn : USD >10.55
    Đơn vị tính : capsule
  • Biệt dược thương mại : Accutane 40 mg capsule
    Giá bán buôn : USD >14.88
    Đơn vị tính : capsule
  • Biệt dược thương mại : Claravis 10 mg capsule
    Giá bán buôn : USD >15.77
    Đơn vị tính : capsule
  • Biệt dược thương mại : Amnesteem 10 mg capsule
    Giá bán buôn : USD >16.4
    Đơn vị tính : capsule
  • Biệt dược thương mại : Claravis 30 mg capsule
    Giá bán buôn : USD >16.45
    Đơn vị tính : capsule
  • Biệt dược thương mại : Claravis 20 mg capsule
    Giá bán buôn : USD >18.7
    Đơn vị tính : capsule
  • Biệt dược thương mại : Amnesteem 20 mg capsule
    Giá bán buôn : USD >19.45
    Đơn vị tính : capsule
  • Biệt dược thương mại : Amnesteem 40 mg capsule
    Giá bán buôn : USD >22.6
    Đơn vị tính : capsule
  • Biệt dược thương mại : Claravis 40 mg capsule
    Giá bán buôn : USD >22.6
    Đơn vị tính : capsule
  • Biệt dược thương mại : Accutane 20 mg capsule
    Giá bán buôn : USD >23.77
    Đơn vị tính : capsule
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Absorica
  • Công ty :
    Sản phẩm biệt dược : Accutane Roche
  • Công ty :
    Sản phẩm biệt dược : Myorisan
  • Công ty :
    Sản phẩm biệt dược : ZENATANE
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00982
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00348
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0004-0155-49
PharmGKB
http://www.pharmgkb.org/drug/PA450128
Wikipedia
http://en.wikipedia.org/wiki/Isotretinoin
RxList
http://www.rxlist.com/cgi/generic/isotret.htm
Drugs.com
http://www.drugs.com/cdi/isotretinoin.html
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