Tìm theo
Isoprenaline
Các tên gọi khác (18 ) :
  • (+-)-Isoprenaline
  • (+-)-Isoproterenol
  • (±)-isoprenaline
  • (±)-isoproterenol
  • 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol
  • 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol
  • 3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol
  • alpha-(Isopropylaminomethyl)protocatechuyl alcohol
  • Isoprenalina
  • Isoprenaline
  • Isoprenalinum
  • Isopropyl noradrenaline
  • Isoproterenol
  • N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine
  • N-isopropyl-β-dihydroxyphenyl-β-hydroxyethylamine
  • N-Isopropylnoradrenaline
  • N-Isopropylnorepinephrine
  • α-(isopropylaminomethyl)protocatechuyl alcohol
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 7683-59-2
ATC: C01CA02, D08AX05
ĐG : Amend
CTHH: C11H17NO3
PTK: 211.2576
Isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H17NO3
Phân tử khối
211.2576
Monoisotopic mass
211.120843415
InChI
InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
InChI Key
InChIKey=JWZZKOKVBUJMES-UHFFFAOYSA-N
IUPAC Name
4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol
Traditional IUPAC Name
isoprenaline
SMILES
CC(C)NCC(O)C1=CC(O)=C(O)C=C1
Độ tan chảy
180
Độ hòa tan
5.86e+00 g/l
logP
1.4
logS
-1.6
pKa (strongest acidic)
9.81
pKa (Strongest Basic)
8.96
PSA
72.72 Å2
Refractivity
58.4 m3·mol-1
Polarizability
23.04 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Isoproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Cơ Chế Tác Dụng : Isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. [PubChem] The pharmacologic effects of isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Dược Động Học :

▧ Route of Elimination :
Excretion following inhalation administration is primarily renal and the major metabolite is the sulfate conjugate of isoproterenol.
Chỉ Định : For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis
Tương Tác Thuốc :
  • Acebutolol Antagonism
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of isoproterenol.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of isoproterenol.
  • Atenolol Antagonism
  • Bisoprolol Antagonism
  • Carvedilol Antagonism
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of isoproterenol.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of isoproterenol.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of isoproterenol.
  • Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, isoproterenol.
  • Esmolol Antagonism
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of isoproterenol.
  • Isocarboxazid Increased arterial pressure
  • Labetalol Antagonism
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Metoprolol Antagonism
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of isoproterenol.
  • Nadolol Antagonism
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of isoproterenol.
  • Oxprenolol Antagonism
  • Phenelzine Increased arterial pressure
  • Pindolol Antagonism
  • Propranolol Antagonism
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
  • Timolol Antagonism
Liều Lượng & Cách Dùng : Gel - Topical
Liquid - Auricular (otic)
Liquid - Topical
Lotion - Topical
Solution - Intramuscular
Solution - Topical
Spray - Topical
Stick - Topical
Swab - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Hospira
    Sản phẩm biệt dược : Isuprel
  • Công ty : Riker
    Sản phẩm biệt dược : Medihaler-Iso
  • Công ty : Kowa Souyaku
    Sản phẩm biệt dược : Proternol L
  • Công ty : Pharmax
    Sản phẩm biệt dược : Saventrine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01064
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3779
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507323
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07056
ChemSpider
http://www.chemspider.com/Chemical-Structure.3647.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25392
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0089-0785-21
PharmGKB
http://www.pharmgkb.org/drug/PA450121
Wikipedia
http://en.wikipedia.org/wiki/Isoproterenol
RxList
http://www.rxlist.com/cgi/generic3/isoproterenol.htm
Drugs.com
http://www.drugs.com/cdi/isoproterenol.html
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